6-CHLORO-2-(METHYLTHIO)-1H-BENZO[D]IMIDAZOLE

Base Information

• Chemical Name: 6-CHLORO-2-(METHYLTHIO)-1H-BENZO[D]IMIDAZOLE
• CAS No.: 7692-57-1
• Molecular Formula: C₈H₇ClN₂S
• Molecular Weight: 198.676
• Hs Code.: 2933990090
• Mol file: 7692-57-1.mol

Synonyms:5-Chloro-1H-benzimidazol-2-yl methyl sulfide;2-Mercaptomethyl-5-chlor-benzimidazol;

Chemical Property of 6-CHLORO-2-(METHYLTHIO)-1H-BENZO[D]IMIDAZOLE

Chemical Property:

• Vapor Pressure: 5E-06mmHg at 25°C
• Boiling Point: 381.6°C at 760 mmHg
• Flash Point: 184.6°C
• PSA: 53.98000
• Density: 1.43g/cm³
• LogP: 2.93820

Purity/Quality:

6-CHLORO-2-(METHYLTHIO)-1H-BENZO[D]IMIDAZOLE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-2-(METHYLTHIO)-1H-BENZO[D]IMIDAZOLE

There total 6 articles about 6-CHLORO-2-(METHYLTHIO)-1H-BENZO[D]IMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

5-chloro-1H-benzoimidazole-2-thiol (25369-78-2) + methyl iodide (74-88-4) → 5-chloro-2-(methylthio)-1H-benzimidazole (7692-57-1)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 20 ℃; for 1h;

DOI:10.1016/S0960-894X(02)00346-3

Reference yield:

5-chloro-1,3-dihydro-2H-benzo[d]imidazole-2-thione (25369-78-2) + methyl iodide (74-88-4) → 6-chloro-2-(methylthio)-1H-benzimidazole + 5-chloro-2-(methylthio)-1H-benzimidazole (7692-57-1)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 4h; Overall yield = 0.850 g; Inert atmosphere;

Reference yield:

4-Chloro-1,2-phenylenediamine (95-83-0) → 5-chloro-2-(methylthio)-1H-benzimidazole (7692-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / potassium hydroxide / ethanol / 2 h / 70 °C

2: 79 percent / potassium hydroxide / ethanol; H₂O / 1 h / 20 °C

With potassium hydroxide; In ethanol; water;

DOI:10.1016/S0960-894X(02)00346-3

upstream raw materials:

5-chloro-1,3-dihydro-2H-benzo[d]imidazole-2-thione

methyl iodide

5-chloro-1H-benzoimidazole-2-thiol

4-Chloro-1,2-phenylenediamine