(3R,5S,E)-((S)-5,6-bis(nitrooxy)hexyl) 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

Base Information

Chemical Name:(3R,5S,E)-((S)-5,6-bis(nitrooxy)hexyl) 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate
CAS No.:1353050-24-4
Molecular Formula:C₂₈H₃₈FN₅O₁₂S
Molecular Weight:687.7
Hs Code.:

Synonyms:(3R,5S,E)-((S)-5,6-bis(nitrooxy)hexyl) 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

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Chemical Property of (3R,5S,E)-((S)-5,6-bis(nitrooxy)hexyl) 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

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Technology Process of (3R,5S,E)-((S)-5,6-bis(nitrooxy)hexyl) 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

There total 4 articles about (3R,5S,E)-((S)-5,6-bis(nitrooxy)hexyl) 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1353050-15-3
(S)-5,6-dinitrooxyhexyl 2-((6R,8S)-8-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate

: 1353050-24-4
(3R,5S,E)-((S)-5,6-bis(nitrooxy)hexyl) 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

Guidance literature:: With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; at 0 - 20 ℃; for 12h;

Reference yield:

: crestor

: 1353050-24-4
(3R,5S,E)-((S)-5,6-bis(nitrooxy)hexyl) 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 12 h / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C

3: morpholine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 12 h

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 20 °C

5: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 0 - 20 °C

With morpholine; 1H-imidazole; dmap; triethylamine tris(hydrogen fluoride); 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1352945-05-1
rosuvastatin allyl ester

: 1353050-24-4
(3R,5S,E)-((S)-5,6-bis(nitrooxy)hexyl) 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C

2: morpholine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 12 h

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 20 °C

4: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 0 - 20 °C

With morpholine; 1H-imidazole; dmap; triethylamine tris(hydrogen fluoride); 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;