(S)-5,6-dinitrooxyhexyl 2-((6R,8S)-8-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate

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Chemical Name:(S)-5,6-dinitrooxyhexyl 2-((6R,8S)-8-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate
CAS No.:1353050-15-3
Molecular Formula:C₄₀H₆₄FN₅O₁₃SSi₂
Molecular Weight:930.209
Hs Code.:

(S)-5,6-dinitrooxyhexyl 2-((6R,8S)-8-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate

Synonyms:(S)-5,6-dinitrooxyhexyl 2-((6R,8S)-8-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate

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Chemical Property of (S)-5,6-dinitrooxyhexyl 2-((6R,8S)-8-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate

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Technology Process of (S)-5,6-dinitrooxyhexyl 2-((6R,8S)-8-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate

There total 4 articles about (S)-5,6-dinitrooxyhexyl 2-((6R,8S)-8-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 861405-29-0
(2S)-6-hydroxy-2-(nitrooxy)hexyl nitrate

: 1353050-14-2
2-((6R,8S)-8-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetic acid

: 1353050-15-3
(S)-5,6-dinitrooxyhexyl 2-((6R,8S)-8-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 5h;

Reference yield:

: crestor

: 1353050-15-3
(S)-5,6-dinitrooxyhexyl 2-((6R,8S)-8-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 12 h / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C

3: morpholine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 12 h

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 20 °C

With morpholine; 1H-imidazole; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1352945-05-1
rosuvastatin allyl ester

: 1353050-15-3
(S)-5,6-dinitrooxyhexyl 2-((6R,8S)-8-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C

2: morpholine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 12 h

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 20 °C

With morpholine; 1H-imidazole; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;