6-fluoro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Base Information

Chemical Name:6-fluoro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid
CAS No.:1335116-53-4
Molecular Formula:C₁₉H₁₃F₄NO₃
Molecular Weight:379.311
Hs Code.:

Synonyms:6-fluoro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

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Chemical Property of 6-fluoro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

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Technology Process of 6-fluoro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

There total 1 articles about 6-fluoro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 600-18-0
2-Oxobutyric acid

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 64465-53-8
4-fluoro-3-methoxyaniline

: 1335116-53-4
6-fluoro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: 3-Trifluoromethylbenzaldehyde; 4-fluoro-3-methoxyaniline; In ethanol; Reflux;

2-Oxobutyric acid; In ethanol; at 20 ℃; Product distribution / selectivity; Reflux;

Reference yield: 99.0%

: 1335116-53-4
6-fluoro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

: 1335116-85-2
6-fluoro-7-hydroxy-3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: With hydrogen bromide; acetic acid; for 120h; Reflux;

Reference yield: 82.0%

: 1335116-53-4
6-fluoro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

: 74-88-4
methyl iodide

: 5188-07-8
sodium thiomethoxide

: 1335116-61-4
methyl 3-methyl-7-(methyloxy)-6-(methylthio)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: 6-fluoro-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid; With sodium hydride; In dimethyl sulfoxide; for 0.333333h;

sodium thiomethoxide; In dimethyl sulfoxide; at 100 ℃; for 2h;

methyl iodide; In dimethyl sulfoxide; at 20 ℃; for 2h;