5-((Aminosulfonyl)amino)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide

Base Information

Chemical Name:5-((Aminosulfonyl)amino)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide
CAS No.:68256-26-8
Molecular Formula:C15H24N4O4S
Molecular Weight:356.4405
Hs Code.:
DSSTox Substance ID:DTXSID20987783
ChEMBL ID:CHEMBL14685

Synonyms:BRN 0444666;5-((Aminosulfonyl)amino)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide;Benzamide, 5-((aminosulfonyl)amino)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-;68256-26-8;CHEMBL14685;SCHEMBL11080243;DTXSID20987783;LS-25642;N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-(sulfamoylamino)benzene-1-carboximidic acid

Suppliers and Price of 5-((Aminosulfonyl)amino)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-((Aminosulfonyl)amino)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.297g/cm³
XLogP3:0.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:356.15182643
Heavy Atom Count:24
Complexity:522

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)NS(=O)(=O)N)OC

Technology Process of 5-((Aminosulfonyl)amino)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide

There total 7 articles about 5-((Aminosulfonyl)amino)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 90763-33-0
N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-5-t-butylaminosulfonamidobenzamide

: 68256-26-8
N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-5-aminosulfonamidobenzamide

Guidance literature:: With trifluoroacetic acid; for 3h; Ambient temperature;
DOI:10.1021/jm00375a009

Reference yield:

: 123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6
1,4-dioxane

: 26116-12-1
1-ethyl-2-pyrrolidinemethanamine

4-methyl 2-chloro 1-3-2-dioxophosphorinane: 4-methyl 2-chloro 1-3-2-dioxophosphorinane

: 2-methoxy-5-sulfamidobenzoic acid

: 68256-26-8
N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-5-aminosulfonamidobenzamide

Guidance literature:: With ammonia; In water;

Reference yield:

: 40751-89-1
2-methoxy-5-nitrobenzoic acid

: 68256-26-8
N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-5-aminosulfonamidobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / 1 h / Heating

2: Et₃N / CH₂Cl₂ / 0.25 h / Ambient temperature

3: 35 percent / Sn, HCl aq. / 4 h / 50 °C

4: Et₃N / CH₂Cl₂ / 0.25 h

5: 58 percent / TFA / 3 h / Ambient temperature

With hydrogenchloride; tin; thionyl chloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00375a009