(+)-(4S)-5,9-bis[(4-methylphenyl)sulfonyl]-4-[(octylthio)methyl]-1,5,9-triazacyclotridecan-2-one

Base Information

• Chemical Name: (+)-(4S)-5,9-bis[(4-methylphenyl)sulfonyl]-4-[(octylthio)methyl]-1,5,9-triazacyclotridecan-2-one
• CAS No.: 467457-55-2
• Molecular Formula: C₃₃H₅₁N₃O₅S₃
• Molecular Weight: 665.983
• Mol file: 467457-55-2.mol

Synonyms:(+)-(4S)-5,9-bis[(4-methylphenyl)sulfonyl]-4-[(octylthio)methyl]-1,5,9-triazacyclotridecan-2-one

Chemical Property of (+)-(4S)-5,9-bis[(4-methylphenyl)sulfonyl]-4-[(octylthio)methyl]-1,5,9-triazacyclotridecan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(4S)-5,9-bis[(4-methylphenyl)sulfonyl]-4-[(octylthio)methyl]-1,5,9-triazacyclotridecan-2-one

There total 5 articles about (+)-(4S)-5,9-bis[(4-methylphenyl)sulfonyl]-4-[(octylthio)methyl]-1,5,9-triazacyclotridecan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

propane-1,3-diol ditosylate (5469-66-9) + (+)-(3S)-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)-4-(octylthio)butanamide (467457-53-0) → (+)-(4S)-5,9-bis[(4-methylphenyl)sulfonyl]-4-[(octylthio)methyl]-1,5,9-triazacyclotridecan-2-one (467457-55-2)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 24h;

DOI:10.1002/1522-2675(200206)85:6<1742::AID-HLCA1742>3.0.CO;2-E

Reference yield:

Octanethiol (111-88-6) → (+)-(4S)-5,9-bis[(4-methylphenyl)sulfonyl]-4-[(octylthio)methyl]-1,5,9-triazacyclotridecan-2-one (467457-55-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / KOH / ethanol / 0.25 h / 20 °C

2: 100 percent / Cu(OAc)2 / 8 h / 20 °C

3: 100 percent / Et₃N / CHCl₃ / 2 h / 20 °C

4: 81 percent / Cs₂CO₃ / dimethylformamide / 24 h / 50 °C

With potassium hydroxide; copper diacetate; caesium carbonate; triethylamine; In ethanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1002/1522-2675(200206)85:6<1742::AID-HLCA1742>3.0.CO;2-E

Reference yield:

ethyl (-)-(3S)-4-iodo-3-(tosylamino)butanoate (147228-22-6) → (+)-(4S)-5,9-bis[(4-methylphenyl)sulfonyl]-4-[(octylthio)methyl]-1,5,9-triazacyclotridecan-2-one (467457-55-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / KOH / ethanol / 0.25 h / 20 °C

2: 100 percent / Cu(OAc)2 / 8 h / 20 °C

3: 100 percent / Et₃N / CHCl₃ / 2 h / 20 °C

4: 81 percent / Cs₂CO₃ / dimethylformamide / 24 h / 50 °C

With potassium hydroxide; copper diacetate; caesium carbonate; triethylamine; In ethanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1002/1522-2675(200206)85:6<1742::AID-HLCA1742>3.0.CO;2-E

upstream raw materials:

propane-1,3-diol ditosylate

(+)-(3S)-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)-4-(octylthio)butanamide

Octanethiol

ethyl (-)-(3S)-4-iodo-3-(tosylamino)butanoate

Downstream raw materials:

(4S)-5,9-bis[(4-methylphenyl)sulfonyl]-4-[(octylsulfinyl)methyl]-1,5,9-triazacyclotridecan-2-one

(-)-(4S)-5,9-bis[(4-methylphenyl)sulfonyl]-4-[(octylsulfonyl)methyl]-1,5,9-triazacyclotridecan-2-one