Technology Process of tert-butyl 3-(6-(3-phenylureido)pyridin-2-yl)piperidine-1-carboxylate
There total 4 articles about tert-butyl 3-(6-(3-phenylureido)pyridin-2-yl)piperidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.5 h / -78 °C
1.2: 20 °C
2.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-acetone complex / 1,4-dioxane / 12 h / 80 °C
3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 12 h / 80 °C
4.1: hydrogen; acetic acid / palladium on carbon / 12 h / 20 °C / 2068.65 Torr
4.2: 12 h / Reflux
With
hydrogen; potassium acetate; sodium carbonate; acetic acid; lithium diisopropyl amide;
1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium(0); [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-acetone complex; palladium on carbon;
In
tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; n-heptane; ethylbenzene; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-acetone complex / 1,4-dioxane / 12 h / 80 °C
2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 12 h / 80 °C
3.1: hydrogen; acetic acid / palladium on carbon / 12 h / 20 °C / 2068.65 Torr
3.2: 12 h / Reflux
With
hydrogen; potassium acetate; sodium carbonate; acetic acid;
1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium(0); [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-acetone complex; palladium on carbon;
In
1,4-dioxane; 1,2-dimethoxyethane; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 12 h / 80 °C
2.1: hydrogen; acetic acid / palladium on carbon / 12 h / 20 °C / 2068.65 Torr
2.2: 12 h / Reflux
With
hydrogen; sodium carbonate; acetic acid;
tetrakis(triphenylphosphine) palladium(0); palladium on carbon;
In
1,2-dimethoxyethane; water;
