(+)-(1S,αR)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol

Base Information

Chemical Name:(+)-(1S,αR)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol
CAS No.:120142-62-3
Molecular Formula:C₁₈H₂₁NO₃
Molecular Weight:299.37
Hs Code.:

Synonyms:(+)-(1S,αR)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(1S,αR)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol

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Technology Process of (+)-(1S,αR)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol

There total 3 articles about (+)-(1S,αR)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 120142-59-8
(1S,αR)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-2-<((R)-1-phenylethyl)carbamoyl>-1-isoquinolinemethanol

: 120142-62-3
(+)-(1S,αR)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol

Guidance literature:: With sodium butanolate; In butan-1-ol; for 5h; Heating;
DOI:10.1021/jo00274a044

Reference yield:

: 22190-45-0
(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)(phenyl)methanone

: 120142-62-3
(+)-(1S,αR)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.88 g / NaBH₄ / methanol; H₂O / 2 h / Ambient temperature

2: 23 percent / CHCl₃ / 1 h / Ambient temperature

3: 80 percent / sodium butoxide / butan-1-ol / 5 h / Heating

With sodium tetrahydroborate; sodium butanolate; In methanol; chloroform; water; butan-1-ol;
DOI:10.1021/jo00274a044

Reference yield:

: 120034-51-7
(+/-)-erythro-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol

: 120142-62-3
(+)-(1S,αR)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 23 percent / CHCl₃ / 1 h / Ambient temperature

2: 80 percent / sodium butoxide / butan-1-ol / 5 h / Heating

With sodium butanolate; In chloroform; butan-1-ol;
DOI:10.1021/jo00274a044