(3,4-Dihydro-6,7-dimethoxy-1-isoquinolinyl)phenylmethanone

Base Information

• Chemical Name: (3,4-Dihydro-6,7-dimethoxy-1-isoquinolinyl)phenylmethanone
• CAS No.: 22190-45-0
• Molecular Formula: C18H17NO3
• Molecular Weight: 295.338
• ChEMBL ID: CHEMBL581931
• DSSTox Substance ID: DTXSID201193200
• Nikkaji Number: J1.310.929J

Synonyms:CHEMBL581931;DTXSID201193200;22190-45-0;(3,4-Dihydro-6,7-dimethoxy-1-isoquinolinyl)phenylmethanone

Chemical Property of (3,4-Dihydro-6,7-dimethoxy-1-isoquinolinyl)phenylmethanone

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 295.12084340
• Heavy Atom Count: 22
• Complexity: 428

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=C2C(=C1)CCN=C2C(=O)C3=CC=CC=C3)OC

Technology Process of (3,4-Dihydro-6,7-dimethoxy-1-isoquinolinyl)phenylmethanone

There total 10 articles about (3,4-Dihydro-6,7-dimethoxy-1-isoquinolinyl)phenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-(3,4-dimethoxyphenethyl)-2-oxo-2-phenylacetamide (160852-78-8) → (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)(phenyl)methanone (22190-45-0)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1055/s-0031-1290655

Reference yield: 71.0%

1-benzyl-6,7-dimethoxy-3,4-dihydro-isoquinoline (4876-00-0) → (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)(phenyl)methanone (22190-45-0)

Guidance literature:

With air; In benzene; Ambient temperature;

DOI:10.1002/hlca.19880710703

Reference yield: 60.0%

N-(3,4-dimethoxyphenethyl)-phenyl acetamide (4876-02-2) → (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)(phenyl)methanone (22190-45-0) + 1-benzyl-6,7-dimethoxy-3,4-dihydro-isoquinoline (4876-00-0)

Guidance literature:

With trichlorophosphate; In toluene; Heating;

DOI:10.1080/00304949709355182

upstream raw materials:

1-benzyl-6,7-dimethoxy-3,4-dihydro-isoquinoline

2-acetyl-1-benzylidene-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

N-(3,4-dimethoxyphenethyl)-phenyl acetamide

(2-bromo-phenyl)-(6,7-dimethoxy-3,4-dihydro-[1]isoquinolyl)-ketone

Downstream raw materials:

(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)(phenyl)methanone

(1S,10bS)-8,9-Dimethoxy-1-phenyl-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinoline

(1S)-1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

(+)-(1S,αR)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 22190-45-0 Methanone, (3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)phenyl-

Send

Send

Metric Ton KG G Pound L ML

Send

Send