(1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-N-(4-hydroxy-butyl)-acetamide

Base Information

Chemical Name:(1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-N-(4-hydroxy-butyl)-acetamide
CAS No.:264218-67-9
Molecular Formula:C₃₂H₄₆N₂O₄
Molecular Weight:522.728
Hs Code.:

Synonyms:(1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-N-(4-hydroxy-butyl)-acetamide

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Chemical Property of (1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-N-(4-hydroxy-butyl)-acetamide

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Technology Process of (1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-N-(4-hydroxy-butyl)-acetamide

There total 11 articles about (1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-N-(4-hydroxy-butyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 264218-65-7
(1R,1'S,5R,8aR)-N-benzyl-2-[3-oxo-1-((1'-phenylmethoxy)hexane)-1,5,6,8a-tetrahydro-oxazolo[3,4-a]pyridin-5-yl]-N-4-hydroxy-butyl acetamide

: 264218-67-9
(1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-N-(4-hydroxy-butyl)-acetamide

Guidance literature:: With potassium hydroxide; In methanol; water; for 18h; Heating;
DOI:10.1021/jo049724+

Reference yield:

: [(1R,5R,8aS)-1-((S)-1-Benzyloxy-hexyl)-3,7-dioxo-8-phenylselanyl-hexahydro-oxazolo[3,4-a]pyridin-5-yl]-acetic acid methyl ester

: 264218-67-9
(1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-N-(4-hydroxy-butyl)-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 65 percent / CeCl₃*7H₂O; NaBH₄ / methanol / 0.25 h

2: 91 percent / 4-dimethylaminopyridine / toluene / 3 h / Heating

3: 91 percent / AIBN; (n-Bu)3SnH / toluene / 0.08 h / Heating

4: KOH / methanol; H₂O / 2 h / 20 °C

5: oxalyl chloride; N,N-dimethylformamide / CH₂Cl₂ / 1 h

6: 82 percent / NaOH / CH₂Cl₂ / 1.5 h

7: 88 percent / KOH / methanol; H₂O / 18 h / Heating

With dmap; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; cerium(III) chloride; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; N,N-dimethyl-formamide; In methanol; dichloromethane; water; toluene; 1: Luche reduction;
DOI:10.1021/jo049724+

Reference yield:

: 1054655-93-4
[(1R,1'S,5R,9R)-3-oxo-1-((1'-phenylmethoxy)hexyl)-1,5,6,8a-tetrahydrooxazolo[3,4-a]pyridin-5-yl]acetic acid chloride

: 264218-67-9
(1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-N-(4-hydroxy-butyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / NaOH / CH₂Cl₂ / 1.5 h

2: 88 percent / KOH / methanol; H₂O / 18 h / Heating

With potassium hydroxide; sodium hydroxide; In methanol; dichloromethane; water;
DOI:10.1021/jo049724+