(1'R,2R,2'S,6R)-N-benzyl-2-{6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-N-(4-hydroxy-butyl)-acetamide

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Chemical Name:(1'R,2R,2'S,6R)-N-benzyl-2-{6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-N-(4-hydroxy-butyl)-acetamide
CAS No.:264218-71-5
Molecular Formula:C₄₂H₅₉N₃O₆S
Molecular Weight:734.013
Hs Code.:

(1'R,2R,2'S,6R)-N-benzyl-2-{6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-N-(4-hydroxy-butyl)-acetamide

Synonyms:(1'R,2R,2'S,6R)-N-benzyl-2-{6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-N-(4-hydroxy-butyl)-acetamide

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Chemical Property of (1'R,2R,2'S,6R)-N-benzyl-2-{6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-N-(4-hydroxy-butyl)-acetamide

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Technology Process of (1'R,2R,2'S,6R)-N-benzyl-2-{6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-N-(4-hydroxy-butyl)-acetamide

There total 10 articles about (1'R,2R,2'S,6R)-N-benzyl-2-{6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-N-(4-hydroxy-butyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 264218-69-1
trifluoromethanesulfonic acid 3-(toluene-4-sulfonylamino)propyl ester

: 264218-67-9
(1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-N-(4-hydroxy-butyl)-acetamide

: 264218-71-5
(1'R,2R,2'S,6R)-N-benzyl-2-{6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-N-(4-hydroxy-butyl)-acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 3h;
DOI:10.1021/jo049724+

Reference yield:

: [(1R,5R,8aS)-1-((S)-1-Benzyloxy-hexyl)-3,7-dioxo-8-phenylselanyl-hexahydro-oxazolo[3,4-a]pyridin-5-yl]-acetic acid methyl ester

: 264218-71-5
(1'R,2R,2'S,6R)-N-benzyl-2-{6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-N-(4-hydroxy-butyl)-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 65 percent / CeCl₃*7H₂O; NaBH₄ / methanol / 0.25 h

2: 91 percent / 4-dimethylaminopyridine / toluene / 3 h / Heating

3: 91 percent / AIBN; (n-Bu)3SnH / toluene / 0.08 h / Heating

4: KOH / methanol; H₂O / 2 h / 20 °C

5: oxalyl chloride; N,N-dimethylformamide / CH₂Cl₂ / 1 h

6: 82 percent / NaOH / CH₂Cl₂ / 1.5 h

7: 88 percent / KOH / methanol; H₂O / 18 h / Heating

8: 84 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 3 h

With dmap; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; cerium(III) chloride; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; water; toluene; 1: Luche reduction;
DOI:10.1021/jo049724+

Reference yield:

: 264218-65-7
(1R,1'S,5R,8aR)-N-benzyl-2-[3-oxo-1-((1'-phenylmethoxy)hexane)-1,5,6,8a-tetrahydro-oxazolo[3,4-a]pyridin-5-yl]-N-4-hydroxy-butyl acetamide

: 264218-71-5
(1'R,2R,2'S,6R)-N-benzyl-2-{6-(2'-phenylmethoxy-1'-hydroxy-heptyl)-1-[3-(toluene-4-sulfonylamino)-propyl]-1,2,3,6-tetrahydro-pyridin-2-yl}-N-(4-hydroxy-butyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / KOH / methanol; H₂O / 18 h / Heating

2: 84 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 3 h

With potassium hydroxide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water;
DOI:10.1021/jo049724+