2-phenyl-3-(trifluoromethyl)benzo[d]imidazo[2,1-b]thiazole

Base Information

• Chemical Name: 2-phenyl-3-(trifluoromethyl)benzo[d]imidazo[2,1-b]thiazole
• CAS No.: 1268167-80-1
• Molecular Formula: C₁₆H₉F₃N₂S
• Molecular Weight: 318.322
• Mol file: 1268167-80-1.mol

Synonyms:2-phenyl-3-(trifluoromethyl)benzo[d]imidazo[2,1-b]thiazole

Chemical Property of 2-phenyl-3-(trifluoromethyl)benzo[d]imidazo[2,1-b]thiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-3-(trifluoromethyl)benzo[d]imidazo[2,1-b]thiazole

There total 6 articles about 2-phenyl-3-(trifluoromethyl)benzo[d]imidazo[2,1-b]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-iodo-2-phenylbenzo[d]imidazo[2,1-b]thiazole (1268167-83-4) + trifluoromethanesulfonic acid diphenyl(trifluoromethyl)sulfonium salt (147531-11-1) → 2-phenyl-3-(trifluoromethyl)benzo[d]imidazo[2,1-b]thiazole (1268167-80-1)

Guidance literature:

With copper; In N,N-dimethyl-formamide; at 60 ℃; for 11h;

DOI:10.1002/anie.201006823

Reference yield: 72.0%

2-phenylimidazo[2,1-b]benzothiazole (17833-07-7) + TMG?CF3I → 2-phenyl-3-(trifluoromethyl)benzo[d]imidazo[2,1-b]thiazole (1268167-80-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 48h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1039/d1ob01417j

Reference yield: 70.0%

2-phenylimidazo[2,1-b]benzothiazole (17833-07-7) + Langlois reagent (2926-29-6) → 2-phenyl-3-(trifluoromethyl)benzo[d]imidazo[2,1-b]thiazole (1268167-80-1)

Guidance literature:

With anthraquinone-2-carboxylic acid; potassium carbonate; trifluoroacetic acid; In dimethyl sulfoxide; at 20 ℃; for 24h; regioselective reaction; Irradiation; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.02.003

upstream raw materials:

3-iodo-2-phenylbenzo[d]imidazo[2,1-b]thiazole

trifluoromethanesulfonic acid diphenyl(trifluoromethyl)sulfonium salt

2-phenylimidazo[2,1-b]benzothiazole

Langlois reagent