2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE

Base Information

• Chemical Name: 2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE
• CAS No.: 17833-07-7
• Molecular Formula: C₁₅H₁₀N₂S
• Molecular Weight: 250.324
• Mol file: 17833-07-7.mol

Synonyms:2-phenylimidazo[2,1-b]benzothiazole

Chemical Property of 2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE

There total 26 articles about 2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-amino-benzthiazole (136-95-8,102337-98-4,84293-42-5) + α-bromoacetophenone (70-11-1) → 2-phenylimidazo[2,1-b]benzothiazole (17833-07-7)

Guidance literature:

In water; isopropyl alcohol; at 100 ℃; for 0.25h; under 11251.1 Torr; Temperature; Solvent; Microwave irradiation; Green chemistry;

DOI:10.1039/c9ra08929b

Reference yield: 89.0%

2-amino-benzthiazole (136-95-8,102337-98-4,84293-42-5) + nitromethane (75-52-5) + benzaldehyde (100-52-7) → 2-phenylimidazo[2,1-b]benzothiazole (17833-07-7)

Guidance literature:

With iron(III) chloride; In neat (no solvent); at 80 ℃; for 6h; Reagent/catalyst; Temperature; Time; Catalytic behavior;

DOI:10.1039/c6ra24183b

Reference yield: 88.0%

2-amino-benzthiazole (136-95-8,102337-98-4,84293-42-5) + acetophenone (98-86-2) → 2-phenylimidazo[2,1-b]benzothiazole (17833-07-7)

Guidance literature:

With iron(III) chloride; zinc(II) iodide; In 1,2-dichloro-benzene; at 110 ℃; for 15h; Reagent/catalyst; Solvent;

DOI:10.1021/ol5028893

upstream raw materials:

2-amino-benzthiazole

α-bromoacetophenone

1,3-benzoxazol-2-amine

2-(2-imino-benzothiazol-3-yl)-1-phenyl-ethanone

Downstream raw materials:

(2-phenyl-benzo[d]imidazo[2,1-b]thiazol-3-yl)-succinic acid

N-(benzo[d]thiazol-2-yl)benzamide

2-phenyl-3-(trifluoromethyl)benzo[d]imidazo[2,1-b]thiazole

2-phenyl-3-thiocyanatobenzo[d]imidazo[2,1-b]thiazole

Refernces

• 1、 Chen, Hong,Yi, Hong,Tang, Zilu,Bian, Changliang,Zhang, Heng,Lei, Aiwen. "External Oxidant-Free Regioselective Cross Dehydrogenative Coupling of 2-Arylimidazoheterocycles and Azoles with H2 Evolution via Photoredox Catalysis". . p. 3220 - 3227. Retrieved 2018.
• 2、 Maddili, Swetha Kameswari,Li, Zhen-Zhen,Kannekanti, Vijaya Kumar,Bheemanaboina, Rammohan R. Yadav,Tuniki, Balaraju,Tangadanchu, Vijai Kumar Reddy,Zhou, Cheng-He. "Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton". . p. 2426 - 2431. Retrieved 2018.
• 3、 Feng, Lei,Li, Shichen,Ma, Chen,Wang, Xinfeng,Wang, Yishou,Yao, Yiming. "A multi pathway coupled domino strategy: I2/ TBHP-promoted synthesis of imidazopyridines and thiazoles via sp3, sp2 and sp C-H functionalization". . p. 5919 - 5927. Retrieved 2022/03/31.
• 4、 Chen, Xiran,Fu, Lianrong,Hao, Xin-Qi,Shi, Linlin,Song, Mao-Ping,Zhu, Xinju,Zhu, Yu-Shen. "Iodine-catalyzed amination of benzothiazoles with KSeCN in water to access primary 2-aminobenzothiazoles". . . Retrieved 2021/09/09.