(2R,3R,3'S)-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-(3'-methoxymethyloxy-3'-phenylpropylamino)-3-phenylpropane

Base Information

Chemical Name:(2R,3R,3'S)-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-(3'-methoxymethyloxy-3'-phenylpropylamino)-3-phenylpropane
CAS No.:153704-71-3
Molecular Formula:C₂₈H₄₅NO₅Si
Molecular Weight:503.755
Hs Code.:

Synonyms:(2R,3R,3'S)-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-(3'-methoxymethyloxy-3'-phenylpropylamino)-3-phenylpropane

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Chemical Property of (2R,3R,3'S)-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-(3'-methoxymethyloxy-3'-phenylpropylamino)-3-phenylpropane

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Technology Process of (2R,3R,3'S)-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-(3'-methoxymethyloxy-3'-phenylpropylamino)-3-phenylpropane

There total 10 articles about (2R,3R,3'S)-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-(3'-methoxymethyloxy-3'-phenylpropylamino)-3-phenylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 153704-70-2
(S)-1-iodo-3-methoxymethyloxy-3-phenylpropane

: 153704-66-6
(2R,3R)-3-amino-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-phenylpropane

: 153704-71-3
(2R,3R,3'S)-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-(3'-methoxymethyloxy-3'-phenylpropylamino)-3-phenylpropane

Guidance literature:: With sodium hydrogencarbonate; In acetonitrile; for 21h; Heating;
DOI:10.1016/S0040-4020(01)88039-X

Reference yield:

: 104196-23-8
(2S,3S)-2,3-epoxy-3-phenyl-1-propanol

: 153704-71-3
(2R,3R,3'S)-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-(3'-methoxymethyloxy-3'-phenylpropylamino)-3-phenylpropane

Guidance literature:: Multi-step reaction with 5 steps

1: NaN₃, NH₄Cl / methanol; H₂O / 10 h / 70 °C

2: 92 percent / Et₃N, DMAP / CH₂Cl₂ / 11 h / Ambient temperature

3: 94 percent / i-Pr₂NEt / CH₂Cl₂ / 22 h / Heating

4: 96 percent / HCO₂NH₄ / 10 percent Pd-C / methanol / 2 h / Ambient temperature

5: 92 percent / NaHCO₃ / acetonitrile / 21 h / Heating

With dmap; sodium azide; ammonium formate; sodium hydrogencarbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4020(01)88039-X

Reference yield:

: 121745-57-1
(2R,3R)-3-azido-3-phenyl-propane-1,2diol

: 153704-71-3
(2R,3R,3'S)-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-(3'-methoxymethyloxy-3'-phenylpropylamino)-3-phenylpropane

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / Et₃N, DMAP / CH₂Cl₂ / 11 h / Ambient temperature

2: 94 percent / i-Pr₂NEt / CH₂Cl₂ / 22 h / Heating

3: 96 percent / HCO₂NH₄ / 10 percent Pd-C / methanol / 2 h / Ambient temperature

4: 92 percent / NaHCO₃ / acetonitrile / 21 h / Heating

With dmap; ammonium formate; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(01)88039-X