(2R,3R)-3-amino-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-phenylpropane

Base Information

Chemical Name:(2R,3R)-3-amino-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-phenylpropane
CAS No.:153704-66-6
Molecular Formula:C₁₇H₃₁NO₃Si
Molecular Weight:325.524
Hs Code.:

Synonyms:(2R,3R)-3-amino-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-phenylpropane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-3-amino-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-phenylpropane

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Technology Process of (2R,3R)-3-amino-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-phenylpropane

There total 4 articles about (2R,3R)-3-amino-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-phenylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 153704-65-5
(2R,3R)-3-azido-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-phenylpropane

: 153704-66-6
(2R,3R)-3-amino-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-phenylpropane

Guidance literature:: With ammonium formate; palladium on activated charcoal; In methanol; for 2h; Ambient temperature;
DOI:10.1016/S0040-4020(01)88039-X

Reference yield:

: 104196-23-8
(2S,3S)-2,3-epoxy-3-phenyl-1-propanol

: 153704-66-6
(2R,3R)-3-amino-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-phenylpropane

Guidance literature:: Multi-step reaction with 4 steps

1: NaN₃, NH₄Cl / methanol; H₂O / 10 h / 70 °C

2: 92 percent / Et₃N, DMAP / CH₂Cl₂ / 11 h / Ambient temperature

3: 94 percent / i-Pr₂NEt / CH₂Cl₂ / 22 h / Heating

4: 96 percent / HCO₂NH₄ / 10 percent Pd-C / methanol / 2 h / Ambient temperature

With dmap; sodium azide; ammonium formate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; water;
DOI:10.1016/S0040-4020(01)88039-X

Reference yield:

: 121745-57-1
(2R,3R)-3-azido-3-phenyl-propane-1,2diol

: 153704-66-6
(2R,3R)-3-amino-1-tert-butyldimethylsilyloxy-2-methoxymethyloxy-3-phenylpropane

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Et₃N, DMAP / CH₂Cl₂ / 11 h / Ambient temperature

2: 94 percent / i-Pr₂NEt / CH₂Cl₂ / 22 h / Heating

3: 96 percent / HCO₂NH₄ / 10 percent Pd-C / methanol / 2 h / Ambient temperature

With dmap; ammonium formate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)88039-X