2-{3-[3-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-pyridin-4-ylethanone

Base Information

• Chemical Name: 2-{3-[3-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-pyridin-4-ylethanone
• CAS No.: 1258008-56-8
• Molecular Formula: C₁₆H₁₃N₃O₄S
• Molecular Weight: 343.363
• Mol file: 1258008-56-8.mol

Synonyms:2-{3-[3-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-pyridin-4-ylethanone

Chemical Property of 2-{3-[3-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-pyridin-4-ylethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{3-[3-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-pyridin-4-ylethanone

There total 1 articles about 2-{3-[3-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-pyridin-4-ylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-oxo-3-(4-pyridyl)propanoate (26377-17-3) + N'-hydroxy-3-(methylsulfonyl)benzimidamide (939999-41-4) → 2-{3-[3-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-pyridin-4-ylethanone (1258008-56-8)

Guidance literature:

In toluene; at 180 ℃; for 0.75h; Microwave irradiation;

Reference yield:

(2-fluorophenyl)hydrazine hydrochloride + 2-{3-[3-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-pyridin-4-ylethanone (1258008-56-8) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 4-(1-(2-fluorophenyl)-4-{3-[3-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-5-yl)pyridine (1258008-96-6)

Guidance literature:

2-{3-[3-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-pyridin-4-ylethanone; N,N-dimethyl-formamide dimethyl acetal; With pyridinium p-toluenesulfonate; In toluene; at 90 ℃; for 2h;

(2-fluorophenyl)hydrazine hydrochloride; With acetic acid; In ethanol; for 12h; Reflux;

upstream raw materials:

ethyl 3-oxo-3-(4-pyridyl)propanoate

N'-hydroxy-3-(methylsulfonyl)benzimidamide

Downstream raw materials:

4-(1-(2-fluorophenyl)-4-{3-[3-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-5-yl)pyridine