(2S)-N-(3-(1H-pyrazol-3-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

Base Information

Chemical Name:(2S)-N-(3-(1H-pyrazol-3-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide
CAS No.:1240521-76-9
Molecular Formula:C₂₂H₂₁N₅OS
Molecular Weight:403.508
Hs Code.:

Synonyms:(2S)-N-(3-(1H-pyrazol-3-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

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Chemical Property of (2S)-N-(3-(1H-pyrazol-3-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

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Technology Process of (2S)-N-(3-(1H-pyrazol-3-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

There total 10 articles about (2S)-N-(3-(1H-pyrazol-3-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 3364-80-5
1,3-thiazole-4-carbaldehyde

: 1240521-75-8
(2S)-N-(3-(1H-pyrazol-3-yl)phenyl)-2-amino-3-phenylpropanamide

: 1240521-76-9
(2S)-N-(3-(1H-pyrazol-3-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

Guidance literature:: 1,3-thiazole-4-carbaldehyde; (2S)-N-(3-(1H-pyrazol-3-yl)phenyl)-2-amino-3-phenylpropanamide; In dichloromethane; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 3364-80-5
1,3-thiazole-4-carbaldehyde

: 1240521-75-8
C₁₈H₁₈N₄O

: 1240521-76-9
C₂₂H₂₁N₅OS

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2012.07.063

Reference yield:

: 59843-77-5
1-(1H-pyrazol-3-yl)-3-nitrobenzene

: 1240521-76-9
(2S)-N-(3-(1H-pyrazol-3-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h

4.1: sodium hydrogencarbonate

5.1: dichloromethane / 1 h

5.2: 1 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;