3364-80-5

Basic information

• Product Name: Thiazole-4-carboxaldehyde
• Synonyms: iazole-4-carboxaldehyde;Thiazole-4-carboxaldehyde 90%;THIAZOLE-4-CARBALDEHYDE;THIAZOLE-4-CARBOXALDEHYDE;4-THIAZOLECARBOXALDEHYDE;1,3-Thiazole-4-carboxaldehyde;4-Thiazolecarboxyaldehyde;Thiazole-4-Carboxyladehyde
• CAS NO: 3364-80-5
• Molecular Formula: C₄H₃NOS
• Molecular Weight: 113.14
• Product Categories: Aldehydes;blocks;Thiazoles
• Mol File: 3364-80-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 60-64°C
• Boiling Point: 222.41 °C at 760 mmHg
• Flash Point: 88.311 °C
• Appearance: Pale brown/Powder
• Density: 1.35 g/cm³
• Vapor Pressure: 0.102mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: Keep Cold
• PKA: 0.51±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: Thiazole-4-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazole-4-carboxaldehyde(3364-80-5)
• EPA Substance Registry System: Thiazole-4-carboxaldehyde(3364-80-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-43-22
• Safety Statements: 26-36/37/39-36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 3364-80-5(Hazardous Substances Data)

Usage

Uses

Thiazole-4-carboxaldehyde is used as a intermediate for pharmaceutical.

InChI:InChI=1/C4H3NOS/c6-1-4-2-7-3-5-4/h1-3H

Upstream product

• 15226-74-1 dicobalt octacarbonyl 
• 34259-99-9 4-bromo-1,3-thiazole 
• 3364-76-9 4-chloromethylthiazole 
• 936371-70-9 N-methoxy-N-methylthiazole-4-carboxamide 
• 3364-79-2 4-dichloromethylthiazole 
• 41040-93-1 4-dibromomethylthiazole 
• 116045-55-7 4-Formyl-2-trimethylsilylthiazole 
• 99185-90-7 N-benzenesulfonyl-N'-(thiazole-4-carbonyl)-hydrazine 

Downstream Products

• 1356458-22-4 4-((4-((4-iodophenyl)(quinolin-8-yl)methylene)piperidin-1-yl)methyl)thiazole 
• 1356458-17-7 N-(2-hydroxyethyl)-N-methyl-4-([⁽²⁾H₆]quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide 
• 111601-03-7 4-styryl-1,3-thiazole 
• 1401460-38-5 C₁₉H₁₉N₇OS₂ 
• 1240521-18-9 (S)-3-phenyl-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)-2-(thiazol-4-ylmethylamino)propanamide 
• 1401460-39-6 C₁₈H₁₆N₆OS₃ 
• 1383385-52-1 C₁₁H₈BrNS 
• 1365626-48-7 C₂₄H₂₇N₅O₂S 
• 1365626-44-3 C₂₁H₂₂N₆OS 
• 1187543-33-4 2-amino-6-sulfanyl-4-(1,3-thiazol-4-yl)pyridine-3,5-dicarbonitrile 
• 7036-04-6 1,3-thiazol-4-ylmethanol 
• 111600-89-6 4-ethynylthiazole 
• 1240521-61-2 (2S)-N-(5-(2-methylamino)pyridine-4-yl)-(1,3,4-thiadiazol-2-yl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide 
• 1240521-50-9 (S)-3-phenyl-N-(2-(pyridin-4-yl)thiazol-5-yl)-2-(thiazol-4-ylmethylamino)-propanamide 

Relevant articles and documents

Palladium-Catalyzed Reductive Carbonylation of (Hetero) Aryl Halides and Triflates Using Cobalt Carbonyl as CO Source

An efficient protocol for the reductive carbonylation of (hetero) aryl halides and triflates under CO gas-free conditions using Pd/Co2(CO)8 and triethylsilane has been developed. The mild reaction conditions, enhanced chemoselectivity and, easy access to heterocyclic and vinyl carboxaldehydes highlights its importance in organic synthesis.

5-THIAZOLE SUBSTITUTED 2-PYRROLIDINE-CARBOXYLIC ACIDS

Anti-viral agents of Formula (1a) wherein: RA represents hydroxy; RB represents 4-tert-butylbenzoyl further substituted in the meta-position by halo or C1-3alkoxy; RC represents 2-thiazolyl, 5-methylthiazol-2-yl

A New Convenient Preparation of 2-, 4-, and 5-Thiazolecarboxaldehydes and Their Conversion into the Corresponding Carbonitrile N-Oxides: Synthesis of 3-Thiazolylisoxazoles and 3-Thiazolylisoxazolines

The title aldehydes are prepared in high yields by quenching 2-lithiothiazole, 4-lithio-, and 5-lithio-2-trimethylsilylthiazole with N-formylmorpholine followed by protodesilylation in the latter two cases.The aldehydes are transformed through their oxime