Quinoxalin-5-amine

Base Information

• Chemical Name: Quinoxalin-5-amine
• CAS No.: 16566-20-4
• Molecular Formula: C8H7N3
• Molecular Weight: 145.164
• Hs Code.: 2933990090
• European Community (EC) Number: 691-821-9
• DSSTox Substance ID: DTXSID90168002
• Nikkaji Number: J1.607.692I
• Wikidata: Q72442007
• Mol file: 16566-20-4.mol

Synonyms:quinoxalin-5-amine;16566-20-4;5-Aminoquinoxaline;5-Quinoxalinamine;Quinoxaline, 5-amino-;5-Quinoxalinylamine;BRN 0119350;5-25-11-00128 (Beilstein Handbook Reference);5-Amino-quinoxaline;SCHEMBL825817;DTXSID90168002;MFCD01684973;AKOS006278189;AB09749;PS-3949;AC-17658;LS-142966;CS-0062621;EN300-259973;A882384;Z1198157683

Chemical Property of Quinoxalin-5-amine

Chemical Property:

• Vapor Pressure: 0.000257mmHg at 25°C
• Melting Point: 92 °C
• Refractive Index: 1.723
• Boiling Point: 323.7 °C at 760 mmHg
• PKA: 2.57±0.30(Predicted)
• Flash Point: 175.7 °C
• PSA: 56.91000
• Density: 1.292 g/cm³
• LogP: 1.27568
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 145.063997236
• Heavy Atom Count: 11
• Complexity: 137

Purity/Quality:

97% ^*data from raw suppliers

5-Aminoquinoxaline 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C2C(=C1)N=CC=N2)N

Technology Process of Quinoxalin-5-amine

There total 9 articles about Quinoxalin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-nitrobenzopyrazine (18514-76-6) → quinoxalin-5-ylamine (16566-20-4)

Guidance literature:

With hydrogenchloride; zinc; In water; Reagent/catalyst;

Reference yield: 74.0%

ethanolamine (141-43-5) + 2,1,3-benzooxadiazol-4-ylamine (767-63-5) → quinoxalin-5-ylamine (16566-20-4)

Guidance literature:

With toluene-4-sulfonic acid; at 165 - 170 ℃; for 12h;

DOI:10.1007/s11172-007-0400-x

Reference yield:

Glyoxal (131543-46-9,107-22-2) + 2,3-diamino-nitrobenzene (3694-52-8) → quinoxalin-5-ylamine (16566-20-4)

Guidance literature:

Glyoxal; 2,3-diamino-nitrobenzene; In ethanol; Reflux;

With palladium 10% on activated carbon; hydrogen; In ethanol; at 70 ℃; for 4h; under 1551.49 - 2068.65 Torr;

upstream raw materials:

1,2,3-triaminobenzene

glyoxal sodium bisulfite

N-quinoxalin-5-yl-acetamide

glyoxal sulfate

Downstream raw materials:

N-acetyl-sulfanilic acid quinoxalin-5-ylamide

3-nitro(quinoxalinylamino)benzoic acid

1-(quinoxalin-5-ylimino)-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)-pentan-2-ol