1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-piperidin-2-one

Base Information

Chemical Name:1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-piperidin-2-one
CAS No.:1092938-56-1
Molecular Formula:C₂₄H₂₇N₃O₂
Molecular Weight:389.497
Hs Code.:

Synonyms:1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-piperidin-2-one

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Chemical Property of 1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-piperidin-2-one

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Technology Process of 1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-piperidin-2-one

There total 6 articles about 1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 4509-90-4
5-bromovaleroyl chloride

: 1092938-52-7
(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-amine

: 1092938-56-1
1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-piperidin-2-one

Guidance literature:: 5-bromovaleroyl chloride; (8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-amine; With triethylamine; In tetrahydrofuran; at 20 - 50 ℃;

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield:

: 917957-11-0
BYK 405879

: 1092938-56-1
1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-piperidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / ethylene glycol / 48 h / 195 °C

1.2: 3 h / 20 °C / pH 4 - 5

2.1: diphenyl phosphoryl azide; triethylamine / 3 h / Heating / reflux

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 20 - 50 °C

4.2: 2 h / 0 °C

With sodium hydroxide; diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethylene glycol;

Reference yield:

: 1046469-25-3
(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazole-5-carboxylic acid

: 1092938-56-1
1-[(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazol-5-yl]-piperidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide; triethylamine / 3 h / Heating / reflux

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 20 - 50 °C

3.2: 2 h / 0 °C

With diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;