Technology Process of (8S)-N,N,2,3-Tetramethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydropyrano[2,3-e]benzimidazole-5-carboxamide
There total 3 articles about (8S)-N,N,2,3-Tetramethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydropyrano[2,3-e]benzimidazole-5-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonium hydroxide;
In
dichloromethane;
for 0.5h;
DOI:10.1021/op800177x
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 0.25 - 16.75h;
Product distribution / selectivity;
- Guidance literature:
-
4-hydroxy-N,N,1,2-tetramethyl-5-[3-(2-methylphenyl)-3-oxopropyl]-1H-benzimidazole-6-carboxamide;
With
potassium tert-butylate; hydrogen;
RuCl2[(S)-Xyl-P-Phos][(S)-DAIPEN];
In
isopropyl alcohol; tert-butyl alcohol;
at 70 ℃;
for 20h;
under 60006 Torr;
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 0.25h;
Further stages. Title compound not separated from byproducts.;
DOI:10.1016/j.tetasy.2008.08.022
