(S)-benzyl 3-(2-tert-butoxy-2-oxo-1-phenylethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

Base Information

Chemical Name:(S)-benzyl 3-(2-tert-butoxy-2-oxo-1-phenylethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate
CAS No.:1352950-63-0
Molecular Formula:C₃₃H₃₇N₃O₅
Molecular Weight:555.674
Hs Code.:

Synonyms:(S)-benzyl 3-(2-tert-butoxy-2-oxo-1-phenylethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

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Chemical Property of (S)-benzyl 3-(2-tert-butoxy-2-oxo-1-phenylethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

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Technology Process of (S)-benzyl 3-(2-tert-butoxy-2-oxo-1-phenylethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

There total 7 articles about (S)-benzyl 3-(2-tert-butoxy-2-oxo-1-phenylethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1352950-62-9
(S)-2-(8-(benzyloxycarbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-2-phenylacetic acid

: 36805-97-7
N,N-dimethylformamide di-tert-butyl acetal

: 1352950-63-0
(S)-benzyl 3-(2-tert-butoxy-2-oxo-1-phenylethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

Guidance literature:: In toluene; at 20 ℃; for 16h; Reflux;

Reference yield:

: 24461-61-8
(R)-Phenylglycine methyl ester

: 1352950-63-0
(S)-benzyl 3-(2-tert-butoxy-2-oxo-1-phenylethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium nitrite; hydrogen bromide / water / 1.5 h / 0 °C

2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 16 h / 20 °C

3: lithium hydroxide / water; methanol / 16 h / 20 °C

4: toluene / 16 h / 20 °C / Reflux

With hydrogen bromide; lithium hydroxide; lithium hexamethyldisilazane; sodium nitrite; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1352950-63-0
(S)-benzyl 3-(2-tert-butoxy-2-oxo-1-phenylethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 16 h / 0 - 20 °C

2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 16 h / 20 °C

3: lithium hydroxide / water; methanol / 16 h / 20 °C

4: toluene / 16 h / 20 °C / Reflux

With pyridine; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;