(S)-tert-butyl 2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-2-phenylacetate

Base Information

Chemical Name:(S)-tert-butyl 2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-2-phenylacetate
CAS No.:1352950-60-7
Molecular Formula:C₂₅H₃₁N₃O₃
Molecular Weight:421.539
Hs Code.:

Synonyms:(S)-tert-butyl 2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-2-phenylacetate

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Chemical Property of (S)-tert-butyl 2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-2-phenylacetate

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Technology Process of (S)-tert-butyl 2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-2-phenylacetate

There total 7 articles about (S)-tert-butyl 2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1352950-63-0
(S)-benzyl 3-(2-tert-butoxy-2-oxo-1-phenylethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

: 1352950-60-7
(S)-tert-butyl 2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-2-phenylacetate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate; for 2h; under 760.051 Torr;

Reference yield:

: 24461-61-8
(R)-Phenylglycine methyl ester

: 1352950-60-7
(S)-tert-butyl 2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-2-phenylacetate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium nitrite; hydrogen bromide / water / 1.5 h / 0 °C

2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 16 h / 20 °C

3: lithium hydroxide / water; methanol / 16 h / 20 °C

4: toluene / 16 h / 20 °C / Reflux

5: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 2 h / 760.05 Torr

With hydrogen bromide; hydrogen; lithium hydroxide; lithium hexamethyldisilazane; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1021-25-6
1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

: 1352950-60-7
(S)-tert-butyl 2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-2-phenylacetate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 16 h / 0 - 20 °C

2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 16 h / 20 °C

3: lithium hydroxide / water; methanol / 16 h / 20 °C

4: toluene / 16 h / 20 °C / Reflux

5: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 2 h / 760.05 Torr

With pyridine; hydrogen; lithium hydroxide; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;