ethyl (2E)-3-{3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]phenyl}-2-propenoate

Base Information

• Chemical Name: ethyl (2E)-3-{3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]phenyl}-2-propenoate
• CAS No.: 638214-97-8
• Molecular Formula: C₁₉H₁₉ClO₄
• Molecular Weight: 346.81
• Mol file: 638214-97-8.mol

Synonyms:ethyl (2E)-3-{3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]phenyl}-2-propenoate

Chemical Property of ethyl (2E)-3-{3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]phenyl}-2-propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2E)-3-{3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]phenyl}-2-propenoate

There total 1 articles about ethyl (2E)-3-{3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]phenyl}-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]benzaldehyde (37687-67-5) → ethyl (2E)-3-{3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]phenyl}-2-propenoate (638214-97-8)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran;

3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]benzaldehyde; In tetrahydrofuran; at 80 ℃; for 21h;

Reference yield:

ethyl (2E)-3-{3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]phenyl}-2-propenoate (638214-97-8) → ethyl 3-[3-chloro-4-hydroxy-5-5-(methyloxy)phenyl]propanoate (638214-98-9)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethyl acetate;

Reference yield:

ethyl (2E)-3-{3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]phenyl}-2-propenoate (638214-97-8) → Ethyl 3-{3-chloro-5-(methyloxy)-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}propanoate (638214-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / platinum(IV) oxide / ethyl acetate

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 19 h / 0 - 20 °C

With tributylphosphine; hydrogen; 1,1'-azodicarbonyl-dipiperidine; platinum(IV) oxide; In tetrahydrofuran; ethyl acetate; 2: Mitsunobu reaction;

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]benzaldehyde

Downstream raw materials:

ethyl 3-[3-chloro-4-hydroxy-5-5-(methyloxy)phenyl]propanoate

3-{3-chloro-5-(methyloxy)-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}propanoic acid

Ethyl 3-{3-chloro-5-(methyloxy)-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}propanoate