ethyl 3-[3-chloro-4-hydroxy-5-5-(methyloxy)phenyl]propanoate

Base Information

• Chemical Name: ethyl 3-[3-chloro-4-hydroxy-5-5-(methyloxy)phenyl]propanoate
• CAS No.: 638214-98-9
• Molecular Formula: C₁₂H₁₅ClO₄
• Molecular Weight: 258.702
• Mol file: 638214-98-9.mol

Synonyms:ethyl 3-[3-chloro-4-hydroxy-5-5-(methyloxy)phenyl]propanoate

Chemical Property of ethyl 3-[3-chloro-4-hydroxy-5-5-(methyloxy)phenyl]propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-[3-chloro-4-hydroxy-5-5-(methyloxy)phenyl]propanoate

There total 3 articles about ethyl 3-[3-chloro-4-hydroxy-5-5-(methyloxy)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (2E)-3-{3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]phenyl}-2-propenoate (638214-97-8) → ethyl 3-[3-chloro-4-hydroxy-5-5-(methyloxy)phenyl]propanoate (638214-98-9)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethyl acetate;

Reference yield:

3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]benzaldehyde (37687-67-5) → ethyl 3-[3-chloro-4-hydroxy-5-5-(methyloxy)phenyl]propanoate (638214-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran

1.2: 21 h / 80 °C

2.1: hydrogen / platinum(IV) oxide / ethyl acetate

With hydrogen; sodium hydride; platinum(IV) oxide; In tetrahydrofuran; ethyl acetate; 1.1: Wittig Reaction;

Reference yield:

5-chlorovanillin (19463-48-0) → ethyl 3-[3-chloro-4-hydroxy-5-5-(methyloxy)phenyl]propanoate (638214-98-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 1 h / Heating / reflux

2.1: sodium hydride / tetrahydrofuran

2.2: 21 h / 80 °C

3.1: hydrogen / platinum(IV) oxide / ethyl acetate

With hydrogen; sodium hydride; caesium carbonate; platinum(IV) oxide; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethyl acetate; 2.1: Wittig Reaction;

upstream raw materials:

ethyl (2E)-3-{3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]phenyl}-2-propenoate

3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]benzaldehyde

5-chlorovanillin

Downstream raw materials:

Ethyl 3-{3-chloro-5-(methyloxy)-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}propanoate

3-{3-chloro-5-(methyloxy)-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}propanoic acid