5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-[2-(2-hydroxy-ethylamino)-4-methoxy-pyrimidin-5-yl]-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Base Information

Chemical Name:5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-[2-(2-hydroxy-ethylamino)-4-methoxy-pyrimidin-5-yl]-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one
CAS No.:1448866-76-9
Molecular Formula:C₂₈H₂₈Cl₂N₆O₃
Molecular Weight:567.475
Hs Code.:

5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-[2-(2-hydroxy-ethylamino)-4-methoxy-pyrimidin-5-yl]-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Synonyms:5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-[2-(2-hydroxy-ethylamino)-4-methoxy-pyrimidin-5-yl]-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

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Chemical Property of 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-[2-(2-hydroxy-ethylamino)-4-methoxy-pyrimidin-5-yl]-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

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Technology Process of 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-[2-(2-hydroxy-ethylamino)-4-methoxy-pyrimidin-5-yl]-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

There total 8 articles about 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-[2-(2-hydroxy-ethylamino)-4-methoxy-pyrimidin-5-yl]-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1416058-70-2
2-[4-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-ylamino]-ethanol

: 1448869-71-3
2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

: 1448866-76-9
5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-[2-(2-hydroxy-ethylamino)-4-methoxy-pyrimidin-5-yl]-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 - 110 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1448869-68-8
2-bromo-5-[(4-chlorophenyl)-hydroxy-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

: 1448866-76-9
5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-[2-(2-hydroxy-ethylamino)-4-methoxy-pyrimidin-5-yl]-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: Methanesulfonic anhydride; triethylamine / dichloromethane / 0.25 h / 5 °C / Inert atmosphere

1.2: 2.75 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water; methanol / 2 h / 20 °C / Inert atmosphere

3.1: diethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 7 h / 80 °C / Inert atmosphere

4.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1.5 h / 80 - 110 °C / Inert atmosphere

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diethylamine; triethylamine; sodium hydroxide; Methanesulfonic anhydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1448869-72-4
2-bromo-5-[(4-chloro-phenyl)-5-chloro-2-methyl-phenylamino]-1-isopropyl-1H-imidazole-4-carboxylic acid

: 1448866-76-9
5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-[2-(2-hydroxy-ethylamino)-4-methoxy-pyrimidin-5-yl]-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 7 h / 80 °C / Inert atmosphere

2: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1.5 h / 80 - 110 °C / Inert atmosphere

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;