1448869-68-8

Upstream product

• 87951-12-0 3-Dimethylamino-2-isocyanacrylsaeure-ethylester 
• 1260793-84-7 1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester 
• 1448869-67-7 2-bromo-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester 
• 104-88-1 4-chlorobenzaldehyde 
• 2999-46-4 Ethyl isocyanoacetate 

Downstream Products

• 1448866-68-9 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-2-(4-methoxy-2-methylamino-pyrimidin-5-yl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1448866-70-3 C₂₉H₂₈Cl₂N₄O₂ 
• 1448866-71-4 3-[5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-4-oxo-1,4,5,6-tetrahydro-pyrrolo[3,4-d]imidazol-2-yl]-4-ethyl-benzonitrile 
• 1448866-73-6 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-(2-dimethylamino-4-methoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1448866-74-7 2-(2-amino-4-methoxy-pyrimidin-5-yl)-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1448866-75-8 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-{2-[(2-hydroxy-ethyl)-methyl-amino]-4-methoxy-pyrimidin-5-yl}-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1448866-76-9 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-[2-(2-hydroxy-ethylamino)-4-methoxy-pyrimidin-5-yl]-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1448869-71-3 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1448866-87-2 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-2-(4-methoxy-pyrimidin-5-yl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1448866-97-4 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-[2-(3-hydroxy-3-methyl-azetidin-1-yl)-4-methoxy-pyrimidin-5-yl]-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1448866-99-6 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-[2-(3-hydroxy-azetidin-1-yl)-4-methoxy-pyrimidin-5-yl]-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1448868-15-2 3-[5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-4-oxo-1,4,5,6-tetrahydro-pyrrolo[3,4-d]imidazol-2-yl]-4-methoxy-benzamide 
• 1448870-55-0 2-bromo-5-[(4-chloro-phenyl)-(4-cyano-2-methyl-phenylamino)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid 
• 1448869-73-5 2-bromo-5-[(4-chloro-phenyl)-5-chloro-2-methyl-phenylamino]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

IMIDAXOPYROLONE COMPOUND AND APPLICATION THEREOF

Disclosed is a novel class of MDM2-p53 inhibitor compounds having an imidaxopyrolone structure, and specifically disclosed are compounds represented by formulas (I-1) and (I-2) and pharmaceutically acceptable salts thereof. (I-1), (I-2)

IMIDAZOPYRROLIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

IMIDAZOPYRROLIDINONE COMPOUNDS

The invention relates to compounds of formula (I): (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.