5-[2-amino-4-(trifluoromethyl)benzyl]-2-chloro-N-[(1R)-1-cyclobutylethyl]-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine

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Chemical Name:5-[2-amino-4-(trifluoromethyl)benzyl]-2-chloro-N-[(1R)-1-cyclobutylethyl]-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine
CAS No.:1616371-93-7
Molecular Formula:C₂₇H₂₇ClF₃N₅
Molecular Weight:513.993
Hs Code.:

Synonyms:5-[2-amino-4-(trifluoromethyl)benzyl]-2-chloro-N-[(1R)-1-cyclobutylethyl]-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine

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Chemical Property of 5-[2-amino-4-(trifluoromethyl)benzyl]-2-chloro-N-[(1R)-1-cyclobutylethyl]-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine

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Technology Process of 5-[2-amino-4-(trifluoromethyl)benzyl]-2-chloro-N-[(1R)-1-cyclobutylethyl]-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine

There total 12 articles about 5-[2-amino-4-(trifluoromethyl)benzyl]-2-chloro-N-[(1R)-1-cyclobutylethyl]-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616371-92-6
2-chloro-N-[(1R)-1-cyclobutylethyl]-6-(3-methylphenyl)-5-[2-nitro-4-(trifluoromethyl)benzyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine

: 1616371-93-7
5-[2-amino-4-(trifluoromethyl)benzyl]-2-chloro-N-[(1R)-1-cyclobutylethyl]-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine

Guidance literature:: With iron; ammonium chloride; In ethanol; water; at 70 ℃; for 16h; Sealed tube;

Reference yield:

: 1338377-74-4
(S)-N-[(1E)-cyclobutylmethylidene]-2-methylpropane-2-sulfinamide

: 1616371-93-7
5-[2-amino-4-(trifluoromethyl)benzyl]-2-chloro-N-[(1R)-1-cyclobutylethyl]-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran; diethyl ether / 6 h / -78 - -40 °C / Inert atmosphere

2: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 0 - 25 °C

3: triethylamine / ethanol / 16 h / 70 °C

4: iron; ammonium chloride / ethanol; water / 16 h / 70 °C / Sealed tube

With hydrogenchloride; iron; ammonium chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; water;

Reference yield:

: 1616372-27-0
(S)-N-[(1R)-1-cyclobutylethyl]-2-methylpropane-2-sulfinamide

: 1616371-93-7
5-[2-amino-4-(trifluoromethyl)benzyl]-2-chloro-N-[(1R)-1-cyclobutylethyl]-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 0 - 25 °C

2: triethylamine / ethanol / 16 h / 70 °C

3: iron; ammonium chloride / ethanol; water / 16 h / 70 °C / Sealed tube

With hydrogenchloride; iron; ammonium chloride; triethylamine; In 1,4-dioxane; methanol; ethanol; water;