5-[2-amino-4-(trifluoromethyl)benzyl]-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

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Chemical Name:5-[2-amino-4-(trifluoromethyl)benzyl]-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile
CAS No.:1616371-94-8
Molecular Formula:C₂₈H₂₇F₃N₆
Molecular Weight:504.558
Hs Code.:

Synonyms:5-[2-amino-4-(trifluoromethyl)benzyl]-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

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Chemical Property of 5-[2-amino-4-(trifluoromethyl)benzyl]-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

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Technology Process of 5-[2-amino-4-(trifluoromethyl)benzyl]-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

There total 13 articles about 5-[2-amino-4-(trifluoromethyl)benzyl]-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1616371-93-7
5-[2-amino-4-(trifluoromethyl)benzyl]-2-chloro-N-[(1R)-1-cyclobutylethyl]-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine

: 1616371-94-8
5-[2-amino-4-(trifluoromethyl)benzyl]-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Guidance literature:: With bis(η3-allyl-μ-chloropalladium(II)); XPhos; In N,N-dimethyl acetamide; at 60 - 120 ℃; for 2h; Inert atmosphere; Sealed tube;

Reference yield:

: 1338377-74-4
(S)-N-[(1E)-cyclobutylmethylidene]-2-methylpropane-2-sulfinamide

: 1616371-94-8
5-[2-amino-4-(trifluoromethyl)benzyl]-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran; diethyl ether / 6 h / -78 - -40 °C / Inert atmosphere

2: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 0 - 25 °C

3: triethylamine / ethanol / 16 h / 70 °C

4: iron; ammonium chloride / ethanol; water / 16 h / 70 °C / Sealed tube

5: XPhos; bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 2 h / 60 - 120 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; bis(η3-allyl-μ-chloropalladium(II)); iron; ammonium chloride; triethylamine; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; N,N-dimethyl acetamide; water;

Reference yield:

: 1616372-27-0
(S)-N-[(1R)-1-cyclobutylethyl]-2-methylpropane-2-sulfinamide

: 1616371-94-8
5-[2-amino-4-(trifluoromethyl)benzyl]-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 0 - 25 °C

2: triethylamine / ethanol / 16 h / 70 °C

3: iron; ammonium chloride / ethanol; water / 16 h / 70 °C / Sealed tube

4: XPhos; bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 2 h / 60 - 120 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; bis(η3-allyl-μ-chloropalladium(II)); iron; ammonium chloride; triethylamine; XPhos; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl acetamide; water;