C₁₉H₂₁OP

Base Information

• Chemical Name: C₁₉H₂₁OP
• CAS No.: 82201-18-1
• Molecular Formula: C₁₉H₂₁OP
• Molecular Weight: 296.349
• Mol file: 82201-18-1.mol

Synonyms:C₁₉H₂₁OP

Chemical Property of C₁₉H₂₁OP

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₉H₂₁OP

There total 5 articles about C₁₉H₂₁OP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(6-Methyl-cyclohex-1-enyl)-diphenyl-phosphane (82201-24-9) → C19H21OP (82201-18-1)

Guidance literature:

With dihydrogen peroxide; In tetrahydrofuran; 1.) 0 deg C, 2.) room temp., 2 h Further oxidizing agent: 40 percent peracetic acid;

DOI:10.1016/S0040-4039(01)82996-8

Reference yield:

2-Methylcyclohexanone (583-60-8) → C19H21OP (82201-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent

2: 1.) s-BuLi / 1.) TMEDA, -45 deg C, 1 h; 0 deg C, 3O min 2.) TMEDA, -45 deg C, 1 h; room temp., overnight

3: 77 percent / 30percent H₂O₂ / tetrahydrofuran / 1.) 0 deg C, 2.) room temp., 2 h Further oxidizing agent: 40 percent peracetic acid

With dihydrogen peroxide; sec.-butyllithium; In tetrahydrofuran;

DOI:10.1016/S0040-4039(01)82996-8

Reference yield:

2-bromo-3-methylcyclohexene (40648-09-7) + 1-bromo-2-methyl-1-cyclohexene (99747-75-8) + Diphenylphosphine oxide (4559-70-0) → C19H21OP (82201-18-1) + (2-methylcyclohex-1-en-1-yl)diphenylphosphine oxide (136339-22-5)

Guidance literature:

With copper(l) iodide; potassium carbonate; sodium iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 110 ℃; for 20h; Overall yield = 35 percent; Overall yield = 0.104 g; Inert atmosphere; Schlenk technique;

DOI:10.1002/ejoc.202100456

upstream raw materials:

(6-Methyl-cyclohex-1-enyl)-diphenyl-phosphane

2-methylcyclohexanone (2,4,6-triisopropylbenzenesulfonyl)hydrazone

2-Methylcyclohexanone

2-bromo-3-methylcyclohexene