65165-92-6

Basic information

• Product Name: DL-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Synonyms: DL-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-;Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-;2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
• CAS NO: 65165-92-6
• Molecular Formula: C₁₉H₁₉N₇O₆
• Molecular Weight: 441.4
• Mol File: 65165-92-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DL-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: DL-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-(65165-92-6)
• EPA Substance Registry System: DL-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-(65165-92-6)

Safety Data

• Hazardous Substances Data: 65165-92-6(Hazardous Substances Data)

Upstream product

• 617-65-2 Glutamic acid 
• 197151-79-4 pteroyl azide 
• 56-86-0 L-glutamic acid 
• 223378-68-5 N¹⁰-(trifluoroacetyl)pyrofolic acid 
• 223378-69-6 pyrofolic acid 
• 197151-80-7 N¹⁰-nitrosopteroyl azide 
• 197151-68-1 pteroyl hydrazide 
• 91871-28-2 N-allyloxycarbonyl α-allyl-L-glutamate 
• 138965-46-5 3-[3-((allyloxy)carbonyl)-5-oxo-1,3-oxazolan-4-yl]propanoic acid 
• 59-30-3 folic acid 
• 4230-33-5 N-(4-aminobenzoyl)-glutamic acid 
• 1004-75-7 2,5,6-triamino-3,4-dihydro-4-pyrimidinone 
• 5221-17-0 2,3-dibromopropanal 

Downstream Products

• 80402-35-3 10-ethoxalylfolic acid 
• 1045703-40-9 [Mn₂(folic acid(-2H))(H₂O)2Cl₂]*H₂O 
• 1045703-45-4 [Zn₂(folic acid(-2H))(H₂O)2Cl₂] 
• 1045703-47-6 [Hg₂(folic acid(-2H))(H₂O)2Cl₂] 
• 712-30-1 6-formylpterin 
• 948-60-7 pterine-6-carboxylic acid 
• 2236-60-4 2-aminopteridin-4(3H)-one 

Relevant articles and documents

Efficient syntheses of pyrofolic acid and pteroyl azide, reagents for the production of carboxyl-differentiated derivatives of folic acid

Reaction of folic acid (1) with excess trifluoroacetic anhydride provides access to both the previously unknown N10-(trifluoroacetyl)pyrrofolic acid (8) and pyrofolic acid (9). Reaction of either of these materials with hydrazine selectively affords pteroyl hydrazide (13), which may be oxidized to pteroyl azide (27) on a large scale (62% overall from I without the need for chromatography). Treatment of 27 with differentially protected glutamates provides a convenient and high-yielding synthesis of differentially protected, optically pure folates.