4R,5S-1-t-butoxycarbonyl-4-(4-chlorophenyl)-5-hydroxymethyl-pyrrolidine-2-one

Base Information

Chemical Name:4R,5S-1-t-butoxycarbonyl-4-(4-chlorophenyl)-5-hydroxymethyl-pyrrolidine-2-one
CAS No.:144564-09-0
Molecular Formula:C₁₆H₂₀ClNO₄
Molecular Weight:325.792
Hs Code.:

Synonyms:4R,5S-1-t-butoxycarbonyl-4-(4-chlorophenyl)-5-hydroxymethyl-pyrrolidine-2-one

Suppliers and Price of 4R,5S-1-t-butoxycarbonyl-4-(4-chlorophenyl)-5-hydroxymethyl-pyrrolidine-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 4R,5S-1-t-butoxycarbonyl-4-(4-chlorophenyl)-5-hydroxymethyl-pyrrolidine-2-one

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of 4R,5S-1-t-butoxycarbonyl-4-(4-chlorophenyl)-5-hydroxymethyl-pyrrolidine-2-one

There total 5 articles about 4R,5S-1-t-butoxycarbonyl-4-(4-chlorophenyl)-5-hydroxymethyl-pyrrolidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 144564-15-8
4R,5S-1-t-butoxycarbonyl-5-t-butyldiphenylsiloxymethyl-4-(4-chlorphenyl)pyrrolidine-2-one

: 144564-09-0
4R,5S-1-t-butoxycarbonyl-4-(4-chlorophenyl)-5-hydroxymethyl-pyrrolidine-2-one

Guidance literature:: With triethylamine hydrofluoride; In tetrahydrofuran; for 120h; Ambient temperature;
DOI:10.1016/S0957-4166(00)82107-2

Reference yield:

: 138629-30-8,138871-56-4
(S)-tert-butyl 2-((tert-butyldiphenylsilyloxy)methyl)-5-oxopyrrolidine-1-carboxylate

: 144564-09-0
4R,5S-1-t-butoxycarbonyl-4-(4-chlorophenyl)-5-hydroxymethyl-pyrrolidine-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) hexamethyldisilazane, BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h

2: 30percent H₂O₂ / ethyl acetate

3: 1.) CuBr*SMe₂, 2.) TMSCl / 1.) ether, -20 deg C, 15 min, 2.) ether, THF, -78 deg C, 1 h

4: 62 percent / triethylammonium fluoride / tetrahydrofuran / 120 h / Ambient temperature

With n-butyllithium; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex; dihydrogen peroxide; triethylamine hydrofluoride; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; ethyl acetate;
DOI:10.1016/S0957-4166(00)82107-2

Reference yield:

: 138871-58-6
(S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

: 144564-09-0
4R,5S-1-t-butoxycarbonyl-4-(4-chlorophenyl)-5-hydroxymethyl-pyrrolidine-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) CuBr*SMe₂, 2.) TMSCl / 1.) ether, -20 deg C, 15 min, 2.) ether, THF, -78 deg C, 1 h

2: 62 percent / triethylammonium fluoride / tetrahydrofuran / 120 h / Ambient temperature

With chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex; triethylamine hydrofluoride; In tetrahydrofuran;
DOI:10.1016/S0957-4166(00)82107-2