2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid
CAS No.:144564-10-3
Molecular Formula:C₁₆H₁₈ClNO₅
Molecular Weight:339.776
Hs Code.:

Synonyms:2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid

Suppliers and Price of 2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of 2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid

There total 6 articles about 2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 144564-09-0
4R,5S-1-t-butoxycarbonyl-4-(4-chlorophenyl)-5-hydroxymethyl-pyrrolidine-2-one

: 144564-10-3
2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid

Guidance literature:: With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; for 1.5h;
DOI:10.1016/S0957-4166(00)82107-2

Reference yield:

: 144564-15-8
4R,5S-1-t-butoxycarbonyl-5-t-butyldiphenylsiloxymethyl-4-(4-chlorphenyl)pyrrolidine-2-one

: 144564-10-3
2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Bu₄NF, aq. AcOH / tetrahydrofuran

2: RuCl₃, NaIO₄ / acetonitrile; H₂O

With ruthenium trichloride; sodium periodate; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; water; acetonitrile;
DOI:10.1016/S0957-4166(00)86204-7

Reference yield:

: 138629-30-8,138871-56-4
(S)-tert-butyl 2-((tert-butyldiphenylsilyloxy)methyl)-5-oxopyrrolidine-1-carboxylate

: 144564-10-3
2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) hexamethyldisilazane, BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h

2: 30percent H₂O₂ / ethyl acetate

3: 1.) CuBr*SMe₂, 2.) TMSCl / 1.) ether, -20 deg C, 15 min, 2.) ether, THF, -78 deg C, 1 h

4: 62 percent / triethylammonium fluoride / tetrahydrofuran / 120 h / Ambient temperature

5: 80 percent / NaIO₄, RuCl₃ / acetonitrile; CCl₄; H₂O / 1.5 h

With ruthenium trichloride; sodium periodate; n-butyllithium; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex; dihydrogen peroxide; triethylamine hydrofluoride; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; tetrachloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/S0957-4166(00)82107-2