1-{5-tert-butyl-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a] pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

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Chemical Name:1-{5-tert-butyl-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a] pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea
CAS No.:1443245-29-1
Molecular Formula:C₃₈H₄₆N₈O₄
Molecular Weight:678.834
Hs Code.:

1-{5-tert-butyl-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a] pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

Synonyms:1-{5-tert-butyl-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a] pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

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Chemical Property of 1-{5-tert-butyl-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a] pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

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Technology Process of 1-{5-tert-butyl-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a] pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

There total 17 articles about 1-{5-tert-butyl-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a] pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1443245-28-0
1-(5-tert-butyl-2-{3-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-phenyl}-2-pyrazol-3-yl)-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

: 1443245-29-1
1-{5-tert-butyl-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a] pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol; at 45 ℃; for 18h;

Reference yield:

: 82560-12-1,1237537-54-0
3-tert-butyl-1H-pyrazole-5-amine

: 1443245-29-1
1-{5-tert-butyl-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a] pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide; cis-N,N'-dimethyl-1,2-diaminocyclohexane; potassium carbonate / toluene / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / 72 h

3: sodium hydroxide / water; ethyl acetate / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 h / 70 °C

5: pyridinium p-toluenesulfonate / methanol / 18 h / 45 °C

With copper(l) iodide; di-isopropyl azodicarboxylate; pyridinium p-toluenesulfonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; cis-N,N'-dimethyl-1,2-diaminocyclohexane; sodium hydroxide; In 1,4-dioxane; methanol; water; ethyl acetate; toluene;

Reference yield:

: 1443242-59-8
2,2,2-trifluoro-N-((1S,4R)-4-hydroxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide

: 1443245-29-1
1-{5-tert-butyl-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a] pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / methanol; water / 3.5 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Inert atmosphere

2.2: 1.5 h / 60 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 h / 70 °C

4.1: pyridinium p-toluenesulfonate / methanol / 18 h / 45 °C

With pyridinium p-toluenesulfonate; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; mineral oil;