1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

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Chemical Name:1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea
CAS No.:1443240-85-4
Molecular Formula:C₄₀H₅₁N₉O₃
Molecular Weight:705.903
Hs Code.:

1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

Synonyms:1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

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Chemical Property of 1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

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Technology Process of 1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

There total 19 articles about 1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1443245-29-1
1-{5-tert-butyl-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a] pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: 1443240-85-4
1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

Guidance literature:: With methanesulfonyl chloride; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield: 40.0%

: 1443245-29-1
1-{5-tert-butyl-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a] pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea

: 124-40-3
dimethyl amine

: 1443240-85-4
1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

Guidance literature:: 1-{5-tert-butyl-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a] pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphtalen-1-yl}-urea; With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

dimethyl amine; In tetrahydrofuran; at 60 ℃; for 20h; Sealed tube;

Reference yield:

: 82560-12-1,1237537-54-0
3-tert-butyl-1H-pyrazole-5-amine

: 1443240-85-4
1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydronaphthalen-1-yl}-urea

Guidance literature:: Multi-step reaction with 6 steps

1: copper(l) iodide; cis-N,N'-dimethyl-1,2-diaminocyclohexane; potassium carbonate / toluene / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / 72 h

3: sodium hydroxide / water; ethyl acetate / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 h / 70 °C

5: pyridinium p-toluenesulfonate / methanol / 18 h / 45 °C

6: methanesulfonyl chloride / dichloromethane / 0.5 h / 20 °C

With copper(l) iodide; di-isopropyl azodicarboxylate; pyridinium p-toluenesulfonate; potassium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; cis-N,N'-dimethyl-1,2-diaminocyclohexane; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; toluene;