N-(4-methyl-3-(3-(pyridin-3-yl)acrylamido)phenyl)-4-(bromomethyl-3-trifluoromethyl)benzamide

Base Information

Chemical Name:N-(4-methyl-3-(3-(pyridin-3-yl)acrylamido)phenyl)-4-(bromomethyl-3-trifluoromethyl)benzamide
CAS No.:1255703-02-6
Molecular Formula:C₂₄H₁₉BrF₃N₃O₂
Molecular Weight:518.333
Hs Code.:

Synonyms:N-(4-methyl-3-(3-(pyridin-3-yl)acrylamido)phenyl)-4-(bromomethyl-3-trifluoromethyl)benzamide

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Chemical Property of N-(4-methyl-3-(3-(pyridin-3-yl)acrylamido)phenyl)-4-(bromomethyl-3-trifluoromethyl)benzamide

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Technology Process of N-(4-methyl-3-(3-(pyridin-3-yl)acrylamido)phenyl)-4-(bromomethyl-3-trifluoromethyl)benzamide

There total 6 articles about N-(4-methyl-3-(3-(pyridin-3-yl)acrylamido)phenyl)-4-(bromomethyl-3-trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261952-01-6
4-methyl-3-(trifluoromethyl)benzoic acid

: 1255703-02-6
N-(4-methyl-3-(3-(pyridin-3-yl)acrylamido)phenyl)-4-(bromomethyl-3-trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogensulfite; sodium bromate / water; Isopropyl acetate / Reflux

2: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 5 h / 20 °C

3: triethylamine / dichloromethane / 5 h / 5 - 20 °C

With sodium bromate; oxalyl dichloride; sodium hydrogensulfite; triethylamine; N,N-dimethyl-formamide; In dichloromethane; Isopropyl acetate; water;

Reference yield:

: 859213-39-1
4-(bromomethyl)-3-(trifluoromethyl)benzoic acid

: 1255703-02-6
N-(4-methyl-3-(3-(pyridin-3-yl)acrylamido)phenyl)-4-(bromomethyl-3-trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 5 h / 20 °C

2: triethylamine / dichloromethane / 5 h / 5 - 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

: 1126-74-5
3-(pyridin-3-yl)acrylic acid

: 1255703-02-6
N-(4-methyl-3-(3-(pyridin-3-yl)acrylamido)phenyl)-4-(bromomethyl-3-trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0.5 h / 5 - 20 °C

2: triethylamine / dichloromethane / 3.5 h / 5 - 20 °C

3: ammonium chloride / ethanol; water / 0.5 h / 70 °C

4: triethylamine / dichloromethane / 5 h / 5 - 20 °C

With ammonium chloride; triethylamine; In ethanol; dichloromethane; water;