1126-74-5Relevant articles and documents
Environmentally benign and energy efficient methodology for condensation: An interesting facet to the classical Perkin reaction
Pawar, Poonam Mahadev,Jarag, Krishna Jagannath,Shankarling, Ganapati Subray
, p. 2130 - 2134 (2011)
We have reported use of biodegradable deep eutectic solvent (DES) based on choline chloride and urea, for the synthesis of cinnamic acid and its derivatives via Perkin reaction. The reaction proceeds efficiently under mild condition without use of additional catalyst with better yields. Ease of recovery and reusability of solvent with consistent activity makes this method efficient and environmentally benign. This method is also energy efficient and easy to handle.
Synthesis of cinnamic acid derivatives in a water-insoluble ionic liquid
Zhang, Wensheng,Xu, Wenjing,Liu, Mei,Yan, Yuerong,Sun, Yuezhi,Zhang, Sheli
, p. 723 - 725 (2011)
A number of cinnamic acid derivatives have been synthesised from commercially available aromatic aldehydes and propanedioic acid in a water-insoluble ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate, [bmim]PF6) in high yields in the presence of small catalytic amounts of piperidine. The ionic liquid can be reused at least five times.
The synthesis of possible degradation products of nicotine.
CASTLE,BURGER
, p. 163 - 165 (1954)
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Strategic Approach to 8-Azacoumarins
Wang, Dong,Wang, Yuxi,Zhao, Junjie,Shen, Meng,Hu, Jianyong,Liu, Zhenlin,Li, Linna,Xue, Furen,Yu, Peng
, p. 984 - 987 (2017)
8-Azacoumarins have emerged as a promising class of compounds but are rarely explored due to challenging access. A novel, general, and practical method is provided for this class of compounds. The key lactonization step employs trans-acrylic acid attached pyridine N-oxides as the starting material, with acetic anhydride as both the activation agent and the solvent. Multiple transformations were involved in this reaction, including conjugate addition, nucleophilic aromatic substitution, and elimination. These studies provide the basis for access to 8-azacoumarins, enabling future work including the discovery and development of novel coumarin-type drugs, fluorescent probes, photolabile protecting groups, and other active molecules.
Iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabled aldehyde C-H methylation
Gong, Pei-Xue,Xu, Fangning,Cheng, Lu,Gong, Xu,Zhang, Jie,Gu, Wei-Jin,Han, Wei
supporting information, p. 5905 - 5908 (2021/06/18)
A practical and general iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabling aldehyde C-H methylation for the synthesis of methyl ketones has been developed. This mild, operationally simple method uses ambient air as the sole oxidant and tolerates sensitive functional groups for the late-stage functionalization of complex natural-product-derived and polyfunctionalized molecules.
Orthoquinone compound, as well as preparation method and medicinal application thereof
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Paragraph 0263-0264; 0267-0268, (2020/04/17)
The invention discloses an active small molecular compound simultaneously targeted to NQO1 and NAMPT, as well as a preparation method and a medicinal application thereof, and particularly relates to an orthoquinone compound or a pharmaceutically acceptable salt, solvate, predrug, ester, raceme and isomer thereof, and a medicine composition comprising the compounds, and applications of these compounds and medicine compositions in preparation of anti-tumor drugs. In the invention, by reasonably jointing an activating substrate tanshinone IIA of the NQO1 and the pharmacophores on the NAMPT inhibitor, the NQO1 substrate/NAMPT inhibitor is obtained, so that the compounds can be reductively activated by the NQO1 and meanwhile can inhibit the activity of the NAMPT, thus consuming the NAD+ and inhibiting biosynthesis of the NAD+ and showing a better tumor inhibiting activity. The orthoquinone compounds or medicine compositions thereof that simultaneously target to the NQO1 and the NAMPT have extensive application prospect and are hopeful to be anti-tumor drugs.
