ethyl 2-methyl-2-{4-[(trifluoromethyl)sulfanyl]phenoxy}propanoate

Base Information

Chemical Name:ethyl 2-methyl-2-{4-[(trifluoromethyl)sulfanyl]phenoxy}propanoate
CAS No.:26002-56-2
Molecular Formula:C13H15 F3 O3 S
Molecular Weight:308.3166
Hs Code.:
Mol file:26002-56-2.mol

Synonyms:Propionicacid, 2-methyl-2-[p-[(trifluoromethyl)thio]phenoxy]-, ethyl ester (8CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2-methyl-2-{4-[(trifluoromethyl)sulfanyl]phenoxy}propanoate

Chemical Property:

Vapor Pressure:0.00237mmHg at 25°C
Boiling Point:288.2°Cat760mmHg
Flash Point:128.1°C
PSA：60.83000
Density:1.26g/cm³
LogP:4.01900

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ethyl 2-methyl-2-{4-[(trifluoromethyl)sulfanyl]phenoxy}propanoate

There total 3 articles about ethyl 2-methyl-2-{4-[(trifluoromethyl)sulfanyl]phenoxy}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1146546-99-7
ethyl 2-methyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propanoate

: 1640084-14-5
(((2-phenylpropan-2-yl)oxy)(trifluoromethyl)sulfane)

: 26002-56-2
ethyl 2-methyl-2-(4-((trifluoromethyl)thio)phenoxy)propanoate

Guidance literature:: With [(1,2-bis(diphenylphosphino)ethane)CuCl]; sodium t-butanolate; In toluene; at 50 ℃; for 2h; Inert atmosphere; Schlenk technique;
DOI:10.1002/anie.201813708

Reference yield:

: 637-07-0
Clofibrate

: 26002-56-2
ethyl 2-methyl-2-(4-((trifluoromethyl)thio)phenoxy)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium acetate; methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II); XPhos / ethanol / 4 h / 80 °C / Inert atmosphere; Schlenk technique

1.2: 8 h / 20 °C / Inert atmosphere; Schlenk technique

2.1: [(1,2-bis(diphenylphosphino)ethane)CuCl]; sodium t-butanolate / toluene / 2 h / 50 °C / Inert atmosphere; Schlenk technique

With [(1,2-bis(diphenylphosphino)ethane)CuCl]; methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II); potassium acetate; sodium t-butanolate; XPhos; In ethanol; toluene;
DOI:10.1002/anie.201813708