N-[3-(tert-butyldimethylsilyl)prop-2-yn-1-yl]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[3-(tert-butyldimethylsilyl)prop-2-yn-1-yl]-4-methylbenzenesulfonamide
• CAS No.: 1427798-08-0
• Molecular Formula: C₁₆H₂₅NO₂SSi
• Molecular Weight: 323.532
• Mol file: 1427798-08-0.mol

Synonyms:N-[3-(tert-butyldimethylsilyl)prop-2-yn-1-yl]-4-methylbenzenesulfonamide

Chemical Property of N-[3-(tert-butyldimethylsilyl)prop-2-yn-1-yl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3-(tert-butyldimethylsilyl)prop-2-yn-1-yl]-4-methylbenzenesulfonamide

There total 1 articles about N-[3-(tert-butyldimethylsilyl)prop-2-yn-1-yl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-methyl-N-prop-2-ynylbenzenesulfonamide (55022-46-3) + tert-butyldimethylsilyl chloride (18162-48-6) → N-[3-(tert-butyldimethylsilyl)prop-2-yn-1-yl]-4-methylbenzenesulfonamide (1427798-08-0)

Guidance literature:

4-methyl-N-prop-2-ynylbenzenesulfonamide; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

tert-butyldimethylsilyl chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol503623m

Reference yield: 85.0%

N-[3-(tert-butyldimethylsilyl)prop-2-yn-1-yl]-4-methylbenzenesulfonamide (1427798-08-0) + Phenyl vinyl ketone (768-03-6,26742-84-7) → C25H33NO3SSi

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃;

DOI:10.1055/s-0036-1588803

Reference yield:

N-[3-(tert-butyldimethylsilyl)prop-2-yn-1-yl]-4-methylbenzenesulfonamide (1427798-08-0) + 1-Bromo-2-phenylacetylene (932-87-6) → N-(3-(tert-butyldimethylsilyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

Guidance literature:

With potassium phosphate; 1,10-Phenanthroline; copper(II) sulfate; In toluene; at 70 ℃; for 16h;

DOI:10.1021/ol503623m

upstream raw materials:

4-methyl-N-prop-2-ynylbenzenesulfonamide

tert-butyldimethylsilyl chloride

Downstream raw materials:

C₂₄H₃₁NO₃SSi

C₂₄H₃₃NO₃SSi