methyl 2-(4-benzyloxyphenyl)-2-methylpropionic acid

Base Information

• Chemical Name: methyl 2-(4-benzyloxyphenyl)-2-methylpropionic acid
• CAS No.: 109492-77-5
• Molecular Formula: C₁₇H₁₈O₃
• Molecular Weight: 270.328
• Mol file: 109492-77-5.mol

Synonyms:methyl 2-(4-benzyloxyphenyl)-2-methylpropionic acid

Chemical Property of methyl 2-(4-benzyloxyphenyl)-2-methylpropionic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(4-benzyloxyphenyl)-2-methylpropionic acid

There total 6 articles about methyl 2-(4-benzyloxyphenyl)-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

methyl 2-[4-(benzyloxy)phenyl]-2-methylpropanoate (109492-91-3) → methyl 2-(4-benzyloxyphenyl)-2-methylpropionic acid (109492-77-5)

Guidance literature:

With sodium hydroxide; In ethanol; for 0.666667h; Heating;

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) → methyl 2-(4-benzyloxyphenyl)-2-methylpropionic acid (109492-77-5)

Guidance literature:

Multi-step reaction with 6 steps

1: HCl

2: 96.5 percent / sodamide / liquid ammonia; tetrahydrofuran / 1 h / -33 °C

3: 32 g / AlCl₃ / benzene / 7 h / Heating

4: 82 percent / K₂CO₃, KI / butan-2-one / Heating

5: 80 percent / NaNH₂ / tetrahydrofuran; liquid ammonia / 1 h / -33 °C

6: 83 percent / 2M-NaOH / ethanol / 0.67 h / Heating

With hydrogenchloride; sodium hydroxide; aluminium trichloride; potassium carbonate; sodium amide; potassium iodide; In tetrahydrofuran; ethanol; ammonia; butanone; benzene;

Reference yield:

4-methoxy-phenyl acetic acid methyl ester (23786-14-3) → methyl 2-(4-benzyloxyphenyl)-2-methylpropionic acid (109492-77-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 96.5 percent / sodamide / liquid ammonia; tetrahydrofuran / 1 h / -33 °C

2: 32 g / AlCl₃ / benzene / 7 h / Heating

3: 82 percent / K₂CO₃, KI / butan-2-one / Heating

4: 80 percent / NaNH₂ / tetrahydrofuran; liquid ammonia / 1 h / -33 °C

5: 83 percent / 2M-NaOH / ethanol / 0.67 h / Heating

With sodium hydroxide; aluminium trichloride; potassium carbonate; sodium amide; potassium iodide; In tetrahydrofuran; ethanol; ammonia; butanone; benzene;

upstream raw materials:

methyl 2-[4-(benzyloxy)phenyl]-2-methylpropanoate

4-Methoxyphenylacetic acid

4-methoxy-phenyl acetic acid methyl ester

methyl 2-(4-hydroxyphenyl)propanoate

Downstream raw materials:

2-(4-Benzyloxy-phenyl)-2-methyl-propan-1-ol

ethyl 2-(4-hydroxyphenyl)-2-methylpropanoate

6-(benzyloxy)-3,3-dimethylbenzofuran-2(3H)-one

ethyl 2-(4-benzyloxyphenyl)-2-methylpropanoate