6,7-dihydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine-5(4H)-carboxylic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: 6,7-dihydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine-5(4H)-carboxylic acid 1,1-dimethylethyl ester
• CAS No.: 1363286-69-4
• Molecular Formula: C₁₈H₂₂N₂O₄
• Molecular Weight: 330.384
• Mol file: 1363286-69-4.mol

Synonyms:6,7-dihydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine-5(4H)-carboxylic acid 1,1-dimethylethyl ester

Chemical Property of 6,7-dihydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine-5(4H)-carboxylic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,7-dihydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine-5(4H)-carboxylic acid 1,1-dimethylethyl ester

There total 6 articles about 6,7-dihydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine-5(4H)-carboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Boc-1,2,3,6-tetrahydropyridine (85838-94-4) → 6,7-dihydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine-5(4H)-carboxylic acid 1,1-dimethylethyl ester (1363286-69-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2: sodium azide; ammonium chloride / ethanol; water / 0.08 h / 150 °C / microwave irradiation

3: hydrogen / palladium 10% on activated carbon / ethanol / 50 °C

4: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C

5: Dess-Martin periodane / dichloromethane / 0.08 h / 80 °C / microwave irradiation

6: Burgess Reagent / tetrahydrofuran / 0.25 h / 120 - 150 °C / microwave irradiation

With sodium azide; Burgess Reagent; hydrogen; ammonium chloride; Dess-Martin periodane; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

4-oxo-3-[(phenoxyacetyl)amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester (1363286-66-1) → 6,7-dihydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine-5(4H)-carboxylic acid 1,1-dimethylethyl ester (1363286-69-4)

Guidance literature:

With Burgess Reagent; In tetrahydrofuran; at 120 - 150 ℃; for 0.25h; microwave irradiation;

Reference yield:

tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate (161157-50-2) → 6,7-dihydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine-5(4H)-carboxylic acid 1,1-dimethylethyl ester (1363286-69-4)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium azide; ammonium chloride / ethanol; water / 0.08 h / 150 °C / microwave irradiation

2: hydrogen / palladium 10% on activated carbon / ethanol / 50 °C

3: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C

4: Dess-Martin periodane / dichloromethane / 0.08 h / 80 °C / microwave irradiation

5: Burgess Reagent / tetrahydrofuran / 0.25 h / 120 - 150 °C / microwave irradiation

With sodium azide; Burgess Reagent; hydrogen; ammonium chloride; Dess-Martin periodane; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water;

upstream raw materials:

tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate

N-Boc-1,2,3,6-tetrahydropyridine

tert-butyl 3-amino-4-hydroxypiperidine-1-carboxylate

4-hydroxy-3-[(phenoxyacetyl)amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Downstream raw materials:

4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine