4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine

Base Information

• Chemical Name: 4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine
• CAS No.: 1363286-71-8
• Molecular Formula: C₁₃H₁₄N₂O₂
• Molecular Weight: 230.266
• Mol file: 1363286-71-8.mol

Synonyms:4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine

Chemical Property of 4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine

There total 7 articles about 4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Boc-1,2,3,6-tetrahydropyridine (85838-94-4) → 4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine (1363286-71-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2: sodium azide; ammonium chloride / ethanol; water / 0.08 h / 150 °C / microwave irradiation

3: hydrogen / palladium 10% on activated carbon / ethanol / 50 °C

4: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C

5: Dess-Martin periodane / dichloromethane / 0.08 h / 80 °C / microwave irradiation

6: Burgess Reagent / tetrahydrofuran / 0.25 h / 120 - 150 °C / microwave irradiation

7: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With sodium azide; Burgess Reagent; hydrogen; ammonium chloride; Dess-Martin periodane; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

6,7-dihydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine-5(4H)-carboxylic acid 1,1-dimethylethyl ester (1363286-69-4) → 4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine (1363286-71-8)

Guidance literature:

6,7-dihydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine-5(4H)-carboxylic acid 1,1-dimethylethyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With sodium carbonate; In dichloromethane;

Reference yield:

tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate (161157-50-2) → 4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine (1363286-71-8)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium azide; ammonium chloride / ethanol; water / 0.08 h / 150 °C / microwave irradiation

2: hydrogen / palladium 10% on activated carbon / ethanol / 50 °C

3: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C

4: Dess-Martin periodane / dichloromethane / 0.08 h / 80 °C / microwave irradiation

5: Burgess Reagent / tetrahydrofuran / 0.25 h / 120 - 150 °C / microwave irradiation

6: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With sodium azide; Burgess Reagent; hydrogen; ammonium chloride; Dess-Martin periodane; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water;

upstream raw materials:

tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate

N-Boc-1,2,3,6-tetrahydropyridine

tert-butyl 3-amino-4-hydroxypiperidine-1-carboxylate

4-hydroxy-3-[(phenoxyacetyl)amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester