Technology Process of 5-(1-ethylsulfonyl-3,6-dihydro-2H-pyridin-4-yl)-3-(5-phenyl-1,3,4-oxadiazol-2-yl)pyridin-2-amine
There total 6 articles about 5-(1-ethylsulfonyl-3,6-dihydro-2H-pyridin-4-yl)-3-(5-phenyl-1,3,4-oxadiazol-2-yl)pyridin-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 4-(6-(tert-butoxycarbonylamino)-5-(5-phenyl-1,3,4-oxadiazol-2-yl)pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 3h;
Ethanesulfonyl chloride;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C
2.1: polyphosphoric acid / 2.42 h / 100 °C
3.1: dmap / dichloromethane; tetrahydrofuran / 48 h / 20 °C
4.1: sodium carbonate / dichlorobis(triethylphosphine)palladium(II) / N,N-dimethyl-formamide / 18 h / 60 - 140 °C / Microwave irradiation
5.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
5.2: 16 h / 20 °C
With
dmap; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid;
dichlorobis(triethylphosphine)palladium(II);
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C
2.1: polyphosphoric acid / 2.42 h / 100 °C
3.1: dmap / dichloromethane; tetrahydrofuran / 48 h / 20 °C
4.1: sodium carbonate / dichlorobis(triethylphosphine)palladium(II) / N,N-dimethyl-formamide / 18 h / 60 - 140 °C / Microwave irradiation
5.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
5.2: 16 h / 20 °C
With
dmap; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid;
dichlorobis(triethylphosphine)palladium(II);
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
