4-N-(4-fluorophenyl)pyridine-3,4-diamine

Base Information

• Chemical Name: 4-N-(4-fluorophenyl)pyridine-3,4-diamine
• CAS No.: 108349-64-0
• Molecular Formula: C₁₁H₁₀FN₃
• Molecular Weight: 203.219
• European Community (EC) Number: 846-872-3
• Mol file: 108349-64-0.mol

Synonyms:4-N-(4-fluorophenyl)pyridine-3,4-diamine;108349-64-0;N4-(4-fluorophenyl)pyridine-3,4-diamine;SCHEMBL16089616;AKOS009282584;EN300-125953;Z1587257404

Chemical Property of 4-N-(4-fluorophenyl)pyridine-3,4-diamine

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 203.08587549
• Heavy Atom Count: 15
• Complexity: 192

Purity/Quality:

99% ^*data from raw suppliers

4-N-(4-Fluorophenyl)pyridine-3,4-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1NC2=C(C=NC=C2)N)F

Technology Process of 4-N-(4-fluorophenyl)pyridine-3,4-diamine

There total 4 articles about 4-N-(4-fluorophenyl)pyridine-3,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-3-nitropyridine (5435-54-1) → N-4-(4-fluorophenyl)pyridine-3,4-diamine (108349-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: POCl₃ / dimethylformamide; toluene / 7 h / 110 °C

2: Et₃N / CHCl₃ / 48 h / 67 °C

3: SnCl₂ / ethanol / 0.75 h / 78 °C

With triethylamine; tin(ll) chloride; trichlorophosphate; In ethanol; chloroform; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm0009383

Reference yield:

N-(4-fluorophenyl)-3-nitropyridin-4-amine (14251-89-9) → N-4-(4-fluorophenyl)pyridine-3,4-diamine (108349-64-0)

Guidance literature:

With tin(ll) chloride; In ethanol; at 78 ℃; for 0.75h;

DOI:10.1021/jm0009383

Reference yield:

4-chloro-3-nitropyridine (13091-23-1) → N-4-(4-fluorophenyl)pyridine-3,4-diamine (108349-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / 48 h / 67 °C

2: SnCl₂ / ethanol / 0.75 h / 78 °C

With triethylamine; tin(ll) chloride; In ethanol; chloroform;

DOI:10.1021/jm0009383

upstream raw materials:

N-(4-fluorophenyl)-3-nitropyridin-4-amine

4-hydroxy-3-nitropyridine

4-chloro-3-nitropyridine