3,5-diisopropyl-4-methoxybenzaldehyde

Base Information

• Chemical Name: 3,5-diisopropyl-4-methoxybenzaldehyde
• CAS No.: 221445-27-8
• Molecular Formula: C₁₄H₂₀O₂
• Molecular Weight: 220.312
• Mol file: 221445-27-8.mol

Synonyms:3,5-diisopropyl-4-methoxybenzaldehyde

Chemical Property of 3,5-diisopropyl-4-methoxybenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-diisopropyl-4-methoxybenzaldehyde

There total 5 articles about 3,5-diisopropyl-4-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,6-diisopropyl anisole (2944-52-7) + trifluoroacetic acid (76-05-1) → 3,5-diisopropyl-4-methoxybenzaldehyde (221445-27-8)

Guidance literature:

With hexamethylenetetramine; at 80 ℃; for 5h; Inert atmosphere;

Reference yield: 79.0%

3,5-diisopropyl-4-hydroxybenzaldehyde (10537-86-7) + dimethyl sulfate (77-78-1) → 3,5-diisopropyl-4-methoxybenzaldehyde (221445-27-8)

Guidance literature:

3,5-diisopropyl-4-hydroxybenzaldehyde; With potassium carbonate; In tetrahydrofuran; for 0.25h; Reflux;

dimethyl sulfate; In tetrahydrofuran; for 21h; Reflux;

DOI:10.1002/chem.201502533

Reference yield:

3,5-diisopropyl-4-hydroxybenzaldehyde (10537-86-7) + methyl iodide (74-88-4) → 3,5-diisopropyl-4-methoxybenzaldehyde (221445-27-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 - 80 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.bioorg.2021.105179

upstream raw materials:

3,5-diisopropyl-4-hydroxybenzaldehyde

dimethyl sulfate

N,N-dimethyl-formamide

methyl iodide

Downstream raw materials:

(Z)-5-(3,5-diisopropyl-4-methoxybenzylidene)-2-thioxothiazolidin-4-one

(Z)-5-(3,5-diisopropyl-4-methoxybenzylidene)-2-(methylsulfanyl)thiazol-4-one

Refernces

• 1、 -. "ALPHAvBETA1 INTEGRIN ANTAGONISTS". . . Retrieved 2020/01/31.
• 2、 -. "Substituted phenol compounds useful for anesthesia and sedation". . . Retrieved 2008/06/13.