1-((1H-imidazol-1-yl)methyl)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol

Base Information

Chemical Name:1-((1H-imidazol-1-yl)methyl)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol
CAS No.:364355-13-5
Molecular Formula:C₂₈H₂₈N₆O₂
Molecular Weight:480.569
Hs Code.:

Synonyms:1-((1H-imidazol-1-yl)methyl)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol

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Chemical Property of 1-((1H-imidazol-1-yl)methyl)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol

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Technology Process of 1-((1H-imidazol-1-yl)methyl)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol

There total 8 articles about 1-((1H-imidazol-1-yl)methyl)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288-32-4
1H-imidazole

: 364354-29-0
5-(4-phenoxyphenyl)-7-(1-oxaspiro[2.5]octan-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

: 364355-13-5
1-((1H-imidazol-1-yl)methyl)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 18h;

Reference yield:

: 262441-40-7
5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4,5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

: 364355-13-5
1-((1H-imidazol-1-yl)methyl)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / tetrahydrofuran; water; acetone / 2 h / 40 °C

2: potassium tert-butylate / dimethyl sulfoxide / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

With hydrogenchloride; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 262433-52-3
4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-one

: 364355-13-5
1-((1H-imidazol-1-yl)methyl)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / dimethyl sulfoxide / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

With potassium tert-butylate; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;