5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4,5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Base Information

• Chemical Name: 5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4,5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• CAS No.: 262441-40-7
• Molecular Formula: C₂₆H₂₆N₄O₃
• Molecular Weight: 442.517
• Mol file: 262441-40-7.mol

Synonyms:5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4,5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Chemical Property of 5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4,5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4,5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

There total 5 articles about 5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4,5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-chloro-5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidine (490030-16-5) → 5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4,5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (262441-40-7)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; at 120 ℃; Further stages;

DOI:10.1016/j.bmcl.2017.10.012

Reference yield:

4-chloro-7-(1,4-dioxaspiro[4.5]decan-8-yl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (262444-48-4) → 5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4,5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (262441-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Pd(PPh₃)4; Na₂CO₃ / 1,2-dimethoxy-ethane; H₂O

2: 80 percent / NH₄OH / dioxane / 120 °C / Parr pressure vessel

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; water; 1: Suzuki coupling;

DOI:10.1016/S0960-894X(02)00195-6

Reference yield:

4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (123148-78-7) → 5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4,5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (262441-40-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / Ph₃P; DEAD / tetrahydrofuran

2: 75 percent / Pd(PPh₃)4; Na₂CO₃ / 1,2-dimethoxy-ethane; H₂O

3: 80 percent / NH₄OH / dioxane / 120 °C / Parr pressure vessel

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; 1: Mitsunobu coupling / 2: Suzuki coupling;

DOI:10.1016/S0960-894X(02)00195-6

upstream raw materials:

4-chloro-5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidine

4,4-ethylenedioxycyclohexan-1-ol

4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

4-chloro-7-(1,4-dioxaspiro[4.5]decan-8-yl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-one