(2R,3R)-2,3-bis(3',5'-dibromophenyl)cyclopropane-1,1-dimethanol

Base Information

Chemical Name:(2R,3R)-2,3-bis(3',5'-dibromophenyl)cyclopropane-1,1-dimethanol
CAS No.:1268519-08-9
Molecular Formula:C₁₇H₁₄Br₄O₂
Molecular Weight:569.913
Hs Code.:

Synonyms:(2R,3R)-2,3-bis(3',5'-dibromophenyl)cyclopropane-1,1-dimethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-2,3-bis(3',5'-dibromophenyl)cyclopropane-1,1-dimethanol

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3R)-2,3-bis(3',5'-dibromophenyl)cyclopropane-1,1-dimethanol

There total 10 articles about (2R,3R)-2,3-bis(3',5'-dibromophenyl)cyclopropane-1,1-dimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1268519-07-8
(2R,3R)-1-(ethoxycarbonyl)-2,3-bis(3',5'-dibromophenyl)cyclopropane-1-carboxylic acid

: 1268519-08-9
(2R,3R)-2,3-bis(3',5'-dibromophenyl)cyclopropane-1,1-dimethanol

Guidance literature:: With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tetasy.2010.10.027

Reference yield:

: 56990-02-4
3,5-dibromobenzaldehyde

: 1268519-08-9
(2R,3R)-2,3-bis(3',5'-dibromophenyl)cyclopropane-1,1-dimethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2.1: methanesulfonamide; (9S,9"S)-9,9"-[phthalazine-1,4-diylbis-(oxy)]bis[10,11-dihydro-6'-methoxycinchonane] / tetrahydrofuran; water; tert-butyl alcohol / 120 h / 0 °C / Inert atmosphere

3.1: thionyl chloride / tetrachloromethane / 4 h / Inert atmosphere; Reflux

3.2: 3 h / 20 °C / Inert atmosphere

4.1: sodium hydride / 1,2-dimethoxyethane / 7 h / 20 °C / Inert atmosphere

5.1: sodium periodate; ruthenium trichloride / tetrachloromethane; water; acetonitrile / 24 h / 20 °C / Inert atmosphere

6.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

With ruthenium trichloride; sodium tetrahydroborate; sodium periodate; thionyl chloride; methanesulfonamide; boron trifluoride diethyl etherate; potassium tert-butylate; sodium hydride; (9S,9"S)-9,9"-[phthalazine-1,4-diylbis-(oxy)]bis[10,11-dihydro-6'-methoxycinchonane]; In tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; water; acetonitrile; tert-butyl alcohol; 1.1: Wittig reaction / 2.1: Sharpless dihydroxylation;
DOI:10.1016/j.tetasy.2010.10.027

Reference yield:

: 1268519-04-5
(1R,2R)-1,2-bis(3,5-dibromophenyl)ethane-1,2-diol

: 1268519-08-9
(2R,3R)-2,3-bis(3',5'-dibromophenyl)cyclopropane-1,1-dimethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / tetrachloromethane / 4 h / Inert atmosphere; Reflux

1.2: 3 h / 20 °C / Inert atmosphere

2.1: sodium hydride / 1,2-dimethoxyethane / 7 h / 20 °C / Inert atmosphere

3.1: sodium periodate; ruthenium trichloride / tetrachloromethane; water; acetonitrile / 24 h / 20 °C / Inert atmosphere

4.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

With ruthenium trichloride; sodium tetrahydroborate; sodium periodate; thionyl chloride; boron trifluoride diethyl etherate; sodium hydride; In tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; water; acetonitrile;
DOI:10.1016/j.tetasy.2010.10.027