[2-(2-tert-butyl-malonyl-Arg(Pbf))-aminoethyl]-ethyl-carbamic acid hydromorphone ester

Base Information

Chemical Name:[2-(2-tert-butyl-malonyl-Arg(Pbf))-aminoethyl]-ethyl-carbamic acid hydromorphone ester
CAS No.:1343495-79-3
Molecular Formula:C₄₈H₆₇N₇O₁₁S
Molecular Weight:950.166
Hs Code.:

Synonyms:[2-(2-tert-butyl-malonyl-Arg(Pbf))-aminoethyl]-ethyl-carbamic acid hydromorphone ester

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Chemical Property of [2-(2-tert-butyl-malonyl-Arg(Pbf))-aminoethyl]-ethyl-carbamic acid hydromorphone ester

Chemical Property:

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Technology Process of [2-(2-tert-butyl-malonyl-Arg(Pbf))-aminoethyl]-ethyl-carbamic acid hydromorphone ester

There total 2 articles about [2-(2-tert-butyl-malonyl-Arg(Pbf))-aminoethyl]-ethyl-carbamic acid hydromorphone ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40052-13-9
mono-tert-butyl malonate

: 1343495-78-2
{2-[H-Arg(Pbf)]-aminoethyl}-ethyl-carbamic acid hydromorphone ester

: 1343495-79-3
[2-(2-tert-butyl-malonyl-Arg(Pbf))-aminoethyl]-ethyl-carbamic acid hydromorphone ester

Guidance literature:: mono-tert-butyl malonate; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 5 ℃; for 0.25h;

{2-[H-Arg(Pbf)]-aminoethyl}-ethyl-carbamic acid hydromorphone ester; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 40052-13-9
mono-tert-butyl malonate

: 1343495-79-3
[2-(2-tert-butyl-malonyl-Arg(Pbf))-aminoethyl]-ethyl-carbamic acid hydromorphone ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 5 ℃; for 3h;

Reference yield:

: 1343495-79-3
[2-(2-tert-butyl-malonyl-Arg(Pbf))-aminoethyl]-ethyl-carbamic acid hydromorphone ester

: 466-99-9
hydromorphone

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid; 3-methyl-phenol / 1 h / 20 °C

2: hydrogenchloride / isopropyl alcohol; diethyl ether

3: Bovine pancreas trypsin / 24 h / 37 °C / pH 8 / Aqueous Tris buffer; Enzymatic reaction

With hydrogenchloride; 3-methyl-phenol; trifluoroacetic acid; Bovine pancreas trypsin; In diethyl ether; isopropyl alcohol;