benzoic acid 2-(2,4-dioxo-5-m-tolylamino-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester

Base Information

• Chemical Name: benzoic acid 2-(2,4-dioxo-5-m-tolylamino-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester
• CAS No.: 221226-72-8
• Molecular Formula: C₂₁H₂₁N₃O₅
• Molecular Weight: 395.415

Synonyms:benzoic acid 2-(2,4-dioxo-5-m-tolylamino-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester

Chemical Property of benzoic acid 2-(2,4-dioxo-5-m-tolylamino-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester

Chemical Property:

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Technology Process of benzoic acid 2-(2,4-dioxo-5-m-tolylamino-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester

There total 2 articles about benzoic acid 2-(2,4-dioxo-5-m-tolylamino-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-[(3-methylphenyl)amino]uracil (4878-46-0) → benzoic acid 2-(2,4-dioxo-5-m-tolylamino-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester (221226-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (Me₃Si)2NH / dimethylformamide / 8 h / Heating

2: CH₂Cl₂ / Ambient temperature

With 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1007/BF02251694

Reference yield:

(2-benzoyloxyethyl)oxymethyl chloride (58305-05-8) + (2,4-bis-trimethylsilanyloxy-pyrimidin-5-yl)-m-tolyl-amine → benzoic acid 2-(2,4-dioxo-5-m-tolylamino-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester (221226-72-8)

Guidance literature:

In dichloromethane; Ambient temperature;

DOI:10.1007/BF02251694

Reference yield: 67.9%

benzoic acid 2-(2,4-dioxo-5-m-tolylamino-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester (221226-72-8) → 1-(2-hydroxy-ethoxymethyl)-5-m-tolylamino-1H-pyrimidine-2,4-dione

Guidance literature:

With ammonia; In methanol; for 24h; Ambient temperature;

DOI:10.1007/BF02251694

upstream raw materials:

(2-benzoyloxyethyl)oxymethyl chloride

5-[(3-methylphenyl)amino]uracil

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